Tierfutter (nur Haussäugetiere)
Tierfutter (abstract)
month: 01 / year: 2020
J Anim Physiol Anim Nutr (Berl). 2020 Jan;104(1):291-299. doi: 10.1111/jpn.13224. Epub 2019 Oct 30.
Moringa oleifera has been considered as a potential functional feed or food, since it contains multiple components beneficial to animal and human. However, little is known about the effects of Moringa oleifera supplementation on productive performances in sows. In the current study, the results showed that dietary Moringa oleifera significantly decreased the farrowing length and the number of stillborn (p < .05), while had an increasing trend in the number of live-born (0.05 < p < .10). Furthermore, 8% Moringa oleifera supplementation significantly elevated protein levels in the colostrum (p < .05); 4% Moringa oleifera lowed serum urea nitrogen of sows after 90 days of gestation (p < .05) and significantly decreased serum glucose on 10 days of lactation (p < .05). Both groups showed significant elevation in serum T-AOC activity (p < .05). The serum malondialdehyde (MDA) of sows declined significantly in 4% Moringa oleifera addition group (p < .05). 8% Moringa oleifera meal significantly elevated serum CAT activity after 60 days of gestation (p < .05), while decreased the serum MDA level and increased the serum GSH-Px activity of sows at 10 days of lactation (p < .05). Of piglets, both two dosages of Moringa oleifera supplementation essentially reduced the serum urea nitrogen (p < .05), and 4% Moringa oleifera meal increased serum total protein (p < .05). In addition, piglets that received 8% Moringa oleifera had the highest serum CAT and SOD activities among all groups (p < .05). The present study indicated that Moringa oleifera supplementation could enhance the reproduction performances, elevate protein levels in the colostrum and improve the serum antioxidant indices in both sows and piglets.
Keywords: Moringa oleifera leave meal; antioxidant; farrowing length; sows.
Tierfutter (full text)
Front Vet Sci. 2020 Feb 26;7:53. doi: 10.3389/fvets.2020.00053. eCollection 2020.
The increased consumption of livestock, poultry, and fish products in people’s diet threatens to drive production toward the use of more and more conventional crops in animal feeds. In this context, alleviating the tightening grain crop supply and ensuring the healthy development of animal husbandry through innovations in protein feedstuff production remain considerable challenges. Moringa oleifera is a miracle tree species with abundant nutrients, high protein biological value, and good feeding effect. As a new protein feedstuff, M. oleifera has great potential in alleviating the feeding crisis. Here, we review available literature regarding the characterization of M. oleifera in the field of animal husbandry in terms of nutrient content, digestion, and absorption characteristics, and feeding effects and present current challenges in using M. oleifera as animal feed.
Tierfutter (abstract)
J Ethnopharmacol. 2018 Dec 26;233:80-86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]
ETHNOPHARMACOLOGICAL RELEVANCE:
Moringa oleifera Lam. (Moringaceae) is an important plant based staple food, known for its nutritional and medicinal value and is usually prescribed by herbal practitioners in Nigeria and in other tropical countries for the treatment of male infertility problems and reproductive diseases in females. Although the aphrodisiac properties and fertility enhancement potential in males have been reported, the underlying mechanisms for the activity remain unclear. In this study, we investigated the influence of supplementing the diet with M. oleifera Lam. leaf powder on reproductive hormones and semen quality of New Zealand White (NZW) rabbits.
MATERIALS AND METHODS:
Thirty-two (32) NZW rabbits of 50:50 ratio bucks to does, were randomly distributed to four treatment groups (n = 4 bucks, n = 4 does per group). Graded levels (0, 5, 10 and 15 g/kg) of M. oleifera Lam. leaf powder was incorporated into rabbit growers pellet. The does and bucks were housed separately in hutches and sheltered under the same environmental conditions with free access to their respective treatment diets for a period of 12 weeks.
RESULTS:
In female rabbits, treatment revealed significant (P < 0.05) dose-dependent reduction in the concentration of serum FSH, LH and oestrogen. While in contrast the highest dose of leaf powder significantly (P < 0.05) increased progesterone and prolactin concentrations remained unaffected. On the other hand, the concentration of FSH and LH in bucks was significantly (P < 0.05) increased in treatment groups compared to the control group. Serum testosterone concentrations were significantly lower in the 5 and 10 g/kg treatment groups. Semen volume, sperm count and motility were significantly improved in a dose dependent manner with increasing amounts of M. oleifera Lam. leaf powder in the diet. CONCLUSIONS: We conclude that M. oleifera Lam. leaf powder supplementation to the diet was more beneficial to male rabbit fertility than the female, where it tended to have a negative impact through the hypothalamic-pituitary-gonadal axis. However, with the varying impact of M. oleifera Lam. leaf powder on the hypothalamic-pituitary-gonadal axis of male and female animals, further investigation is necessary to determine the mechanism through which it operates.
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Milchbildung beim Menschen (full text)
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2018.
Moringa (Moringa oleifera) leaves contain vitamins, minerals, and essential amino acids as well as a number of glycosides. It is used as a galactogogue in Asia,[1] particularly in the Philippines where it is called malunggay. Two small studies from the Philippines indicate that it might have some activity as a galactogogue in mothers of preterm infants.[2][3] Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[4] Moringa oleifera leaves are widely used as a food and medicine in Asia and Africa and one small study found no adverse effects in nursing mothers who ingested moringa leaves.[2] No data exist on the safety of Moringa in nursing infants. Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site.
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Tierfutter (full text)
Abstract
To evaluate the effect of feeding Moringa (Moringa oleifera) as green fodder on feed intake, milk yield, microbial protein synthesis, and blood profile, a study was conducted on twenty lactating crossbred cows in Anand district of Gujarat. Cows were divided into two groups of ten each, based on milk yield (9-10 kg/d), fat content (3.5-3.8%) and stage of lactation (av. 60 days in milk). Cows in control group were fed 3.0 kg each chaffed wheat and pulse straw, 15.0 kg green hybrid Napier grass and 5.0 kg cattle feed (23.0% CP; 4.0% EE), Whereas, cows in experimental group were fed 15.0 kg Moringa green fodder (by replacing 15.0 kg hybrid Napier) for 90 days. Nutrient requirement was adjusted by reducing quantity of cattle feed (3.5 kg). Study revealed that milk yield and fat content increased
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Tierfutter (full text)
ABSTRACT
This study evaluated the effects of feeding transition Holstein cows with Moringa oleifera leaf meal (MOLM) on antioxidant enzymes, haematological profile and milk production. Forty-eight pregnant Holstein cows received increasing levels of Moringa oleifera leaf meal (MOLM) at M0: Control; M30: 8.33 g MOLM /100 kg BW and M60: 16.66 g MOLM /100 kg BW. Blood samples were collected to determine haematology, antioxidant enzymes and biochemistry. Milk was sampled to determine yield, composition, antioxidant status (MTAC) and somatic cell count (SCC). White blood cells (WBC) and red blood cells (RBC) were high in M60 group than those in M0 (P = 0.02) and (P = 0.03) respectively. Cows in M60 treatment group had higher (P < 0.01) serum superoxide dismutase (SOD) and total antioxidant capacity (STAC) than M30 and M0 treatment groups. Although, milk yield and body weight were not (P > 0.05) affected by treatment, cows in M60 group were recorded with the highest milk fat (P < 0.01), protein (P = 0.01) and MTAC (P < 0.01) values. In conclusion, supplementing MOLM (M60) to transition dairy cows was shown to improve blood biochemistry, antioxidant status and udder health. Moreover, milk composition and milk antioxidant capacity but not milk yield improved with supplementation of MOLM (M60).
Tierfutter / Abstract
Food Res Int. 2018 Apr;106:317-334. doi: 10.1016/j.foodres.2017.12.079. Epub 2018 Jan 4.
Abstract
Research on the use of various parts of the Moringa oleifera Lam. plant (M. oleifera) as a nutritional and neutraceutical resource for human and animal diets has increased in recent years, emanating from the widespread use of the plant in traditional cuisines and medicinal remedies in several regions of the world. Analytical studies have identified M. oleifera as an important source of essential nutrients; rich in protein, essential amino acids, minerals, and vitamins, with a relatively low amount of antinutrients. It is also a rich source of other bio active compounds including flavonoids and phenolic compounds; with several studies detailing demonstrated in vitro and in vivo functional properties, most substantially, antioxidant activities. Moringa oleifera consumption has been reported to improve the health status, feed conversion efficiency, growth performance and product quality of several livestock species, at dietary inclusion rates generally not exceeding 5% of total dry matter intake. Fortification of processed foods with M. oleifera has been reported to increase nutritional value, some organoleptic properties, oxidative stability and product shelf life; with a notable need for further analytical and consumer studies in the development of these products. There is a paucity of literature detailing clinical studies, nutrient bioavailability, toxicity and the mode of action of the bioactive compounds to which the health claims associated with M. oleifera consumption are attributed. Many of these are not yet fully understood; therefore more research in these areas is required in order to fully utilize the potential benefits of this plant in human and livestock nutrition.
Keywords: Fortification; Functional bio-compounds; Livestock production; Moringa oleifera; Neutraceuticals; Phytochemicals.
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Tierfutter / Abstract
month: 12 year: 2018
J Ethnopharmacol. 2018 Dec 26;233:80-86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]
Abstract
J Ethnopharmacol. 2018 Dec 26;233:80-86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]
ETHNOPHARMACOLOGICAL RELEVANCE:
Moringa oleifera Lam. (Moringaceae) is an important plant based staple food, known for its nutritional and medicinal value and is usually prescribed by herbal practitioners in Nigeria and in other tropical countries for the treatment of male infertility problems and reproductive diseases in females. Although the aphrodisiac properties and fertility enhancement potential in males have been reported, the underlying mechanisms for the activity remain unclear. In this study, we investigated the influence of supplementing the diet with M. oleifera Lam. leaf powder on reproductive hormones and semen quality of New Zealand White (NZW) rabbits.
MATERIALS AND METHODS:
Thirty-two (32) NZW rabbits of 50:50 ratio bucks to does, were randomly distributed to four treatment groups (n = 4 bucks, n = 4 does per group). Graded levels (0, 5, 10 and 15 g/kg) of M. oleifera Lam. leaf powder was incorporated into rabbit growers pellet. The does and bucks were housed separately in hutches and sheltered under the same environmental conditions with free access to their respective treatment diets for a period of 12 weeks.
RESULTS:
In female rabbits, treatment revealed significant (P < 0.05) dose-dependent reduction in the concentration of serum FSH, LH and oestrogen. While in contrast the highest dose of leaf powder significantly (P < 0.05) increased progesterone and prolactin concentrations remained unaffected. On the other hand, the concentration of FSH and LH in bucks was significantly (P < 0.05) increased in treatment groups compared to the control group. Serum testosterone concentrations were significantly lower in the 5 and 10 g/kg treatment groups. Semen volume, sperm count and motility were significantly improved in a dose dependent manner with increasing amounts of M. oleifera Lam. leaf powder in the diet.
CONCLUSIONS:
We conclude that M. oleifera Lam. leaf powder supplementation to the diet was more beneficial to male rabbit fertility than the female, where it tended to have a negative impact through the hypothalamic-pituitary-gonadal axis. However, with the varying impact of M. oleifera Lam. leaf powder on the hypothalamic-pituitary-gonadal axis of male and female animals, further investigation is necessary to determine the mechanism through which it operates.
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Tierfutter / Abstract
month: 05 year: 2018
Animal. 2018 May;12(5):964-972. doi: 10.1017/S1751731117002336. Epub 2017 Oct 9.
Replacement of conventional feedstuffs with cheap non-conventional ingredients may improve livestock performance and the quality of their products, particularly milk. The study considered the effects of Moringa oleifera (MO) foliage in replacement of berseem clover (BC) on feed utilisation and lactational performance in Nubian goats. A total of 16 lactating Nubian does, weighing 36.2±0.8 kg, were randomly assigned to four experimental treatments containing 0, 125, 250 and 375 g of MO per kg diet to replace 0 (M0), 25 (M25), 50 (M50) and 75% (M75) of BC (on dry matter (DM) basis) in a quadruplicated 4×4 Latin square design. The MO diets increased (P<0.01) feed intake and nutrient digestibility. Feeding MO diets improved (P<0.01) ruminal volatile fatty acids, acetate and propionate but reduced (P<0.01) valerate and iso-butyrate. Moringa diets increased (P<0.01) serum total protein, albumin and glucose but decreased (P<0.05) cholesterol and triglycerides. Milk yield and energy corrected milk, and milk total solids, fat and energy content were increased (P<0.01) in MO diets. Yields of milk components and energy were greater (P<0.05) for MO diets than for control diet. Milk total saturated fatty acids and athrogenicity index were lower (P<0.01), and unsaturated fatty acids, conjugated fatty acids and UFA/SFA ratio higher (P<0.05) for MO diets. It is concluded that feeding MO to replace 75% DM of BC improved feed utilisation, ruminal fermentation, and milk yield and quality in lactating Nubian goats.
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Tierfutter / Abstract
month: 02 year: 2018
J Anim Physiol Anim Nutr (Berl). 2018 Feb;102(1):194-203. doi: 10.1111/jpn.12678. Epub 2017 Jun 12.
This contribution reports the effects of Moringa oleifera leaves (MOLs) meal on the growth performances, nutrient digestibility, carcass trait, meat quality, antioxidant capacity and biochemical parameters of growing New Zealand white rabbits. The MOL was substituted for alfalfa meal at levels of 0, 10%, 20% and 30% to obtain respective diets MOL0, MOL10, MOL20 and MOL30. Each treatment was replicated five times with 10 rabbits per replicate. Results showed the average daily weight gain (ADWG) and feed conversion ratio (FCR) of rabbits fed MOL20 diet were significantly better (p < 0.05) than those of other three dietary groups. Liver and spleen index of rabbits fed MOL20 and MOL30 diets was significantly higher (p < 0.05) than that of the groups fed with lower M. oleifera leaves (MOL0, MOL10). The meat drip loss of rabbits fed with diet MOL10 was significantly lower (p < 0.05) than that of rabbits fed other diets. All rabbits fed MOL dietary groups had lower (p < 0.05) shear force of longissimus dorsi than the group without M. oleifera leaves. No significant differences were found in the digestibility of crude fibre (CF), crude fat (EE), ash, crude protein (CP) and nitrogen-free extract (NFE) among the dietary groups. Moringa oleifera leaves also have a significant impact on serum albumin (ALB), low-density lipoprotein cholesterol (LDLC), triiodothyroxine (T3 ) and tetraiodothyroxine (T4 ) values and the activity of superoxide dismutase (SOD) and catalase (CAT) in serum and liver. The results indicated that M. oleifera leaves could be developed as a good feed source, and it not only could substitute for alfalfa meal well but also has a significant effect on growth performance, meat quality, antioxidant and biochemical parameters of rabbits.
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Tierfutter / Abstract
month: 12 year: 2017
Trop Anim Health Prod. 2017 Dec;49(8):1685-1688. doi: 10.1007/s11250-017-1377-6. Epub 2017 Aug 13.
Two experiments were conducted to evaluate the effect of feed restriction on intake of Moringa oleifera(MO) or Leucaena leucocephala (LL) and growth of rabbits. In experiment one, 45 rabbits (male and female) weighing 1.18 ± 0.15 kg were used. They were randomly distributed to three feed restriction treatments (20, 30, and 40%) with 15 rabbits each (9 females and 6 males) and they were offered M. oleifera (MO) ad libitum. In experiment two, 45 growing male rabbits weighing 0.63 ± 0.113 kg were used. They were randomly assigned to 0, 20, and 30% feed restriction diets, and they have free access to L. leucocephala (LL). Intake of MO increased (P < 0.05) conforming feed restriction increased (40.6, 52.9, and 55.2 g/day of MO for 20, 30, and 40%, respectively). Daily liveweight gain and feed conversion did not differ (P > 0.05), and economic efficiency was similar among treatments. Consumption of LL increased (P < 0.05) in rabbits under the 30% restriction treatment in comparison to that of rabbits restricted 20% (46.0 and 44.4 g/day, respectively). Total feed intake (LL + feed) was highest in 20% restricted rabbits (108.0, 100.8, and 93.2 g/day for 20, 30, and 0%, respectively). Daily liveweight gain and feed conversion were not affected by feed restriction (P > 0.05). Economic efficiency improved twice in feed-restricted rabbits (2.0 and 2.3 for 20 and 30%, respectively) in contrast to that of the control 0% group (1.1). The results suggest that rabbits restricted up to 30% and supplemented with either MO or LL did not affect growth performance and reduced feed cost.
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Tierfutter / Full Text
S Selim, MF Seleiman, MM Hassan, AA Saleh… — Animals, 2021
Simple Summary: Rabbit meat is mostly preferred by consumers owing to its high nutritive value and potential health benefits. However, rabbit meat is commonly more prone to lipid peroxidation during storage, with negative effects on quality traits of meat, due to its elevated level of unsaturation of fatty acids. Moringa oleifera leaves have gained great interest owing to their high nutritional value and low anti-nutritional factors. Moringa oleifera leaves could possibly avoid oxidation damage and exhibit antioxidant activities that can conquer free radicals and reactive oxygen species synthesis. Therefore, the objective of the current study was to evaluate the effects of feeding Moringa oleifera leaves on performance, carcass characteristics, antioxidant capacity, blood biochemical constituents, meat quality, and fatty acids profile of growing rabbits. Moringa oleifera leaves supplementation improved weight gain, feed conversion ratio, antioxidant status, and meat quality characteristics. Dietary Moringa oleifera leaves supplementation enhanced PUFA contents, n-3 fatty acid, crude protein, and color of meat, but lowered the relative content of ether extract of the meat. Our findings suggested that Moringa oleifera could be used at a level of 1.5 g/kg of the growing rabbits’ diets with beneficial impacts on performance and the nutritional value of the meat.
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Tierfutter / Abstract
SM El-Shamy, HH Salama, AA Aboamer, MM Shaaban… — Egyptian Journal of Food …, 2021
Moringa oleifer tree products are riches in various bioactive ingredients that have a good role in dairy products. This work aimed to study the effect of adding different Moringa tree products (oil, leave, and cake) in ewe’s rations on milk composition as well as chemical, sensory and microbiological properties of the resultant yoghurt. Thirty-five lactating Barki ewes were randomly assigned into five groups. Each group was feed diet containing different ratios and type of Moringa products. The first group was control (C) The other four groups were classed as follow: Group (1): feed 2.5% Moringa seed cake: (MC1); Group (2): feed 5% Moringa seed cake: (MC2). Group (3): feed 1% Kg /DM Moringa oil (MO) Group (4): feed 15% of total DM Moringa leaves (ML). The chemical compositions of milk as well as the microbiological properties of the resulting yoghurt were studied fresh and during storage time. Results revealed that milk composition significantly (P<0.05) increased with diet fed on MC1 as compared to control. The observed pH differences between different yoghurts treatments are attributed to differences in chemical composition and high total solids of milk between groups. The diacetyl and acetaldehyde contents of yoghurt samples were higher in treatment than the control. The count of S. thermophilus and L. bulgaricus in all treated yoghurt samples was higher than in control, while no significant difference observed in the counts of S. thermophilus and L. bulgaricus, either in the control or between yoghurt treatments. The yoghurt produced from the dairy ewes’ feeding on Moringa oleifera product had good chemical and microbiological properties. So, using it was concluded that feeding Moringa oleifera products is effective in the feeding of dairy ewes’ and other ruminant animals.
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Tierfutter / Abstract
P Priya, KS Ajith, K Ally, K Shyama… — Journal of Veterinary and …, 2020
A study was conducted to compare the lactation performance of Malabari goats fed on two different complete feeds containing Moringa (T2) and fodder sorghum (T3) with those fed on conventional ration (T1). The animals in group T1 were fed on conventional ration consisting of compounded feed mixture (CFM) having 17.89 per cent crude protein (CP) and 68.90 per cent total digestible nutrient (TDN) along with green grass. Complete feed containing moringa leaves fed to goats in T2 group had 15.85 per cent CP and 66.85 per cent TDN while T3 group was fed on complete feed containing sorghum having 15.90 per cent CP and 65.86 per cent TDN, respectively. The roughage:concentrate ratio was maintained at 30:70. The average daily dry matter intake of goats in the three groups, T1, T2 and T3 were 1.46, 1.67 and 1.58 kg, respectively. The average daily milk yield of goats in groups T1, T2 and T3 were found to be similar to each other i.e., 0.81, 0.96 and 0.83 litre respectively (P>0.05). Hence it was concluded that the feeding of complete feed did affect neither the dry matter intake nor the milk yield of lactating Malabari goats.
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Tierfutter / Full Text
month: 07 / year: 2020
Animals (Basel). 2020 Jun 29;10(7):E1117. doi: 10.3390/ani10071117.
The use of plant extracts as supplemental additives in ruminant diets shows beneficial effects. This study evaluated the effects of different doses of Moringa oleifera leaf extract (MOE) on milk production and milk composition in ewes and on preweaning performance of their lambs. At different doses, MOE supplementation did not affect overall productive traits in ewes and lambs and did not have negative effects on milk production and milk quality.
Abstract
The objective this study was to evaluate the effect of different doses of Moringa oleifera leaf extract (MOE) on milk production and milk composition in ewes and on preweaning performance of their lambs. Twenty-four lactating ewes were housed individually with their lambs and assigned to four groups in a completely randomized design. The treatments included a basal diet without MOE (MOE0) or a basal diet supplemented with either 20 mL MOE per ewe per day (MOE20), 40 mL MOE per ewe per day (MOE40) or 60 mL MOE per ewe per day (MOE60). Over 45 days, milk production was recorded weekly and individual milk samples were collected for chemical analysis. Milk yield, fat-corrected milk and daily yields were similar among the four treatments. The supply of MOE did not affect ewe weaning efficiency and average daily gain or litter weaning weight of the lambs. Overall, the results from this study showed that dietary supplementation of hydroalcoholic extracts of Moringa oleifera leaves at doses of 20, 40 or 60 mL/ewes/d in lactating ewes does not have negative effects on milk yield, milk composition or lamb performance.
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Tierfutter / Abstract
J Anim Physiol Anim Nutr (Berl). 2020 Jan;104(1):126-135. doi: 10.1111/jpn.13209. Epub 2019 Sep 18.
Moringa stem meal (MSM) with a high level of crude fibre (CF) might be developed and utilized in herbivorous geese as an unconventional feedstuff. The aim of this study was to investigate the effect of the MSM level in the diet on the growth performance, slaughter performance, breast meat quality and serum biochemical parameters in geese from 22 to 70 days of age. A one-factor completely randomized design was adopted in our study. A total of one thousand eight 21-day-old geese were randomly divided into six groups, with six replicates per group and 28 birds per replicate. The geese were fed diets containing MSM levels of 0, 20, 40, 60, 80 or 100 g/kg during day 22-70. The dietary MSM level had no effect (p > .05) on the final body weight (BW), average daily gain (ADG) or average daily feed intake (ADFI). The feed/gain ratio (F/G) increased linearly (p < .001) as the dietary MSM level increased. No differences (p > .05) were observed in the slaughter performance, meat quality and the relative organ weight (except for thymus) of the geese (p > .05). The relative weight of the thymus in the geese fed diets with supplementation of MSM was higher than that in the non-supplemented MSM control group (p < .05). In addition, 100 g MSM/kg of diet decreased the serum glucose (GLU) level (p < .05) and increased the alanine transaminase (ALT) enzyme activity (p = .03). Dietary MSM levels of no more than 60 g/kg had no effects on the growth performance and slaughter performance, whereas diets with 100 g MSM/kg increased the F/G and serum ALT enzyme activity, as well as decreasing the serum GLU level. Therefore, MSM provided at a reasonable level could be developed as an unconventional feedstuff for geese at the finisher period.
month: 12 year: 2018
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Tierfutter / Full Text
J Ethnopharmacol. 2018 Dec 26;233:80-86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]
J Ethnopharmacol. 2018, 26. Dezember; 233: 80-86. doi: 10.1016 / j.jep.2018.12.036. [Epub vor Druck]
Abstract
Ethnopharmacological relevance: Moringa oleifera Lam. (Moringaceae) is an important plant based staple food, known for its nutritional and medicinal value and is usually prescribed by herbal practitioners in Nigeria and in other tropical countries for the treatment of male infertility problems and reproductive diseases in females. Although the aphrodisiac properties and fertility enhancement potential in males have been reported, the underlying mechanisms for the activity remain unclear. In this study, we investigated the influence of supplementing the diet with M. oleifera Lam. leaf powder on reproductive hormones and semen quality of New Zealand White (NZW) rabbits.
Materials and methods: Thirty-two (32) NZW rabbits of 50:50 ratio bucks to does, were randomly distributed to four treatment groups (n = 4 bucks, n = 4 does per group). Graded levels (0, 5, 10 and 15 g/kg) of M. oleifera Lam. leaf powder was incorporated into rabbit growers pellet. The does and bucks were housed separately in hutches and sheltered under the same environmental conditions with free access to their respective treatment diets for a period of 12 weeks.
Results: In female rabbits, treatment revealed significant (P < 0.05) dose-dependent reduction in the concentration of serum FSH, LH and oestrogen. While in contrast the highest dose of leaf powder significantly (P < 0.05) increased progesterone and prolactin concentrations remained unaffected. On the other hand, the concentration of FSH and LH in bucks was significantly (P < 0.05) increased in treatment groups compared to the control group. Serum testosterone concentrations were significantly lower in the 5 and 10 g/kg treatment groups. Semen volume, sperm count and motility were significantly improved in a dose dependent manner with increasing amounts of M. oleifera Lam. leaf powder in the diet.
Conclusions: We conclude that M. oleifera Lam. leaf powder supplementation to the diet was more beneficial to male rabbit fertility than the female, where it tended to have a negative impact through the hypothalamic-pituitary-gonadal axis. However, with the varying impact of M. oleifera Lam. leaf powder on the hypothalamic-pituitary-gonadal axis of male and female animals, further investigation is necessary to determine the mechanism through which it operates.
Keywords: Fertility hormones; Moringa oleifera Lam. leaf; Rabbit; Semen quality.
Tierfutter / Abstract
month: 10 year: 2016
Trop Anim Health Prod. 2016 Oct;48(7):1427-33. doi: 10.1007/s11250-016-1111-9. Epub 2016 Jul 26.
Trop Anim Health Prod. 2016 Okt; 48 (7): 1427–33. doi: 10.1007 / s11250-016-1111-9. Epub 2016 26. Juli.
The present study was carried out to investigate changes in milk yield and composition of Najdi ewes fed 25 % Moringa oleifera (MOD) or Moringa peregrina (MPD) leaf diets as a supplement to alfalfa hay diet (AHD). Thirty ewes (average 55 kg, 2 years old) were randomly sorted into three experimental groups with 10 animals each and were fed for a 6-week period with these diets (AHD, MOD, or MPD). Diets dry matter, crude protein, and crude fiber were comparable, while fat, nitrogen-free extract (NFE), neutral detergent fiber (NDF), acid detergent fiber (ADF), metabolizable energy (ME), total phenolic, and antioxidant activity varied (p ≤ 0.05) between the diets. Feeding ewes with MOD increased (p ≤ 0.05) the milk yield compared to those fed AHD while milk composition was similar (p ≤ 0.05) between treatments. The concentration of malondialdehyde (MDA) in the ewes‘ milk and serum was lower (p ≤ 0.05) for MOD, while the total antioxidant capacity, catalase activity, and vitamin C contents were increased (p ≤ 0.05). The serum cholesterol and glucose of the ewes were lower (p ≤ 0.05) for those fed MOD. Moringadiets increased (p ≤ 0.05) average daily weight gain of lambs compared to those fed alfalfa diets. The results obtained showed that the inclusion of Moringa, especially M. oleifera, in the diet of Najdi ewes can improve milk yield and quality.
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Tierfutter / Abstract
Abstract
Methane (CH4) emission from nonruminant livestock, particularly equines, is a colossal burden for veterinarians worldwide. In view of this, the present context was investigated to predict the antimethanogenic attributes of Moringa oleifera L. associated phytocomponents by targeting methyl-coenzyme M reductase (MCR) receptor in horses using in silico tools. Initially, the pharmacokinetics and ADME (absorption, distribution, metabolism, and excretion) properties of 26 phytocomponents were analyzed using Lipinski’s rule of five and Swiss ADME tool, respectively. Among all the tested phytocomponents, 3,5-bis(1,1-dimethylethyl)-phenol, Kaempferol, Moringyne, Niazimisin, and Tetradecanoic acid showed drug-likeness traits with no violation. The molecular docking analysis of selected phytocomponents against MCR receptor was carried out using Hex 8.0.0 docking software. Results estimated the highest binding energy of Tetradecanoic acid against MCR receptor with maximum docking E-value of −142.98 KJ/mol, followed by Niazimisin (−133.98 KJ/mol), Kaempferol (−110.36 KJ/mol), 3,5-bis(1,1-dimethylethyl)-phenol (−93.72 KJ/mol), and Moringyne (−92.62 KJ/mol). In conclusion, Tetradecanoic acid can be utilized as a pronounced antimethanogenic agent in order to develop efficacious CH4 mitigating drugs by inhibiting the methanogenesis mechanism. Most importantly, this in silico outcomes can certainly reduce the cost of in vivo studies strategy toward the development of antimethanogenic drugs for horses in the future.
Allgemein / meist Zusammenfassungen (Reviews)
Allgemein (full text)
A Review of the Phytochemical and Pharmacological Characteristics of Moringa oleifera.
J Pharm Bioallied Sci. 2018 Oct-Dec;10(4):181-191. doi: 10.4103/JPBS.JPBS_126_18.
Moringa oleifera is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have shown the ability of this plant to exhibit analgesic, anti-inflammatory, antipyretic, anticancer, antioxidant, nootropic, hepatoprotective, gastroprotective, anti-ulcer, cardiovascular, anti-obesity, antiepileptic, antiasthmatic, antidiabetic, anti-urolithiatic, diuretic, local anesthetic, anti-allergic, anthelmintic, wound healing, antimicrobial, immunomodulatory, and antidiarrheal properties. This review is a comprehensive summary of the phytochemical and pharmacological activities as well as the traditional and therapeutic uses of this plant. M. oleifera has wide traditional and pharmacological uses in various pathophysiological conditions. We will review the various properties of M. oleifera (drumstick tree) and focus on its various medicinal properties. We think that it is an attractive subject for further experimental and clinical investigations.
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Allgemein (full text)
Phytochemistry and Pharmacology of Moringa oleifera Lam.
J Pharmacopuncture. 2017 Sep;20(3):194-200. doi: 10.3831/KPI.2017.20.022. Epub 2017 Sep 30.
Moringa oleifera Lam. or munga is one of the most important plant widely cultivated in India. It belongs to family Moringaceae. This plant is widely used as nutritional herb and contains valuable pharmacological action like anti-asthmatic, anti-diabetic, hepatoprotective, anti-inflammatory, anti- fertility, anti-cancer, anti-microbial, anti-oxidant, cardiovascular, anti-ulcer, CNS activity, anti-allergic, wound healing, analgesic, and antipyretic activity, Moringa oleifera Lam. The plant is also known as Horse – radish tree, Drumstick tree. Every part of this plant contains a valuable medicinal feature. It contain rich source of the vitamin A, vitamin C and milk protein. Different types of active phytoconstituents like alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and fats are present. This plant is also found in the tropical regions. Some other constituents are niazinin A, niazinin B and niazimicin A, niaziminin B. The present review discusses the phytochemical composition, medicinal uses & pharmacological activity of this plant.
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Allgemein (full text)
Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.
Nutrients. 2018 Mar 12;10(3). pii: E343. doi: 10.3390/nu10030343.
Moringa oleifera Lam. (M. oleifera), which belongs to the Moringaceae family, is a perennial deciduous tropical tree, and native to the south of the Himalayan Mountains in northern India. M. oleifera is rich in proteins, vitamin A, minerals, essential amino acids, antioxidants, and flavonoids, as well as isothiocyanates. The extracts from M. oleifera exhibit multiple nutraceutical or pharmacological functions including anti-inflammatory, antioxidant, anti-cancer, hepatoprotective, neuroprotective, hypoglycemic, and blood lipid-reducing functions. The beneficial functions of M. oleifera are strongly associated with its phytochemicals such as flavonoids or isothiocyanates with bioactivity. In this review, we summarize the research progress related to the bioactivity and pharmacological mechanisms of M. oleifera in the prevention and treatment of a series of chronic diseases-including inflammatory diseases, neuro-dysfunctional diseases, diabetes, and cancers-which will provide a reference for its potential application in the prevention and treatment of chronic diseases or health promotion.
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Allgemein (full text)
Moringa Genus: A Review of Phytochemistry and Pharmacology
Front Pharmacol. 2018; 9: 108. Published online 2018 Feb 16.
Moringa is a genus of medicinal plants that has been used traditionally to cure wounds and various diseases such as colds and diabetes. In addition, the genus is also consumed as a source of nutrients and widely used for purifying water. The genus consists of 13 species that have been widely cultivated throughout Asia and Africa for their multiple uses. The purpose of this review is to provide updated and categorized information on the traditional uses, phytochemistry, biological activities, and toxicological research of Moringa species in order to explore their therapeutic potential and evaluate future research opportunities. The literature reviewed for this paper was obtained from PubMed, ScienceDirect, and Google Scholar journal papers published from 1983 to March 2017. Moringa species are well-known for their antioxidant, anti-inflammatory, anticancer, and antihyperglycemic activities. Most of their biological activity is caused by their high content of flavonoids, glucosides, and glucosinolates. By documenting the traditional uses and biological activities of Moringa species, we hope to support new research on these plants, especially on those species whose biological properties have not been studied to date.
Moringa is a genus of medicinal plants that has been used traditionally to cure wounds and various diseases such as colds and diabetes. In addition, the genus is also consumed as a source of nutrients and widely used for purifying water. The genus consists of 13 species that have been widely cultivated throughout Asia and Africa for their multiple uses. The purpose of this review is to provide updated and categorized information on the traditional uses, phytochemistry, biological activities, and toxicological research of Moringa species in order to explore their therapeutic potential and evaluate future research opportunities. The literature reviewed for this paper was obtained from PubMed, ScienceDirect, and Google Scholar journal papers published from 1983 to March 2017. Moringa species are well-known for their antioxidant, anti-inflammatory, anticancer, and antihyperglycemic activities. Most of their biological activity is caused by their high content of flavonoids, glucosides, and glucosinolates. By documenting the traditional uses and biological activities of Moringa species, we hope to support new research on these plants, especially on those species whose biological properties have not been studied to date
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Allgemein (full text)
MINI REVIEW ARTICLE
Front. Pharmacol., 17 December 2020 | https://doi.org/10.3389/fphar.2020.566783
Moringa oleifera Lam and its Therapeutic Effects in Immune Disorders
Moringa oleifera Lam., a plant native to tropical forests of India, is characterized by its versatile application as a food additive and supplement therapy. Accumulating evidence shows that Moringa plays a critical role in immune-related diseases. In this review, we cover the history, constituents, edibility, and general medicinal value of Moringa. The effects of Moringa in treating immune disorders are discussed in detail. Moringa can not only eliminate pathogens, including bacteria, fungi, viruses, and parasites, but also inhibit chronic inflammation, such as asthma, ulcerative colitis, and metabolic diseases. Additionally, Moringa can attenuate physical and chemical irritation-induced immune disorders, such as metal intoxication, drug side effects, or even the adverse effect of food additives. Autoimmune diseases, like rheumatoid arthritis, atopic dermatitis, and multiple sclerosis, can also be inhibited by Moringa. Collectively, Moringa, with its multiple immune regulatory bioactivities and few side effects, has a marked potential to treat immune disorders.
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Allgemein (full text)
Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease.
Antioxidants (Basel). 2017 Nov 16;6(4). pii: E91. doi: 10.3390/antiox6040091.
Moringa Oleifera (MO), a plant from the family Moringacea is a major crop in Asia and Africa. MO has been studied for its health properties, attributed to the numerous bioactive components, including vitamins, phenolic acids, flavonoids, isothiocyanates, tannins and saponins, which are present in significant amounts in various components of the plant. Moringa Oleifera leaves are the most widely studied and they have shown to be beneficial in several chronic conditions, including hypercholesterolemia, high blood pressure, diabetes, insulin resistance, non-alcoholic liver disease, cancer and overall inflammation. In this review, we present information on the beneficial results that have been reported on the prevention and alleviation of these chronic conditions in various animal models and in cell studies. The existing limited information on human studies and Moringa Oleiferaleaves is also presented. Overall, it has been well documented that Moringa Oleifera leaves are a good strategic for various conditions associated with heart disease, diabetes, cancer and fatty liver.
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Allgemein (full text)
Application of Moringa (Moringa oleifera) as Natural Feed Supplement in Poultry Diets.
Animals (Basel). 2019 Jul 9;9(7):431. doi: 10.3390/ani9070431.
Application of natural herbs with a view to enhancing production performance and health status has created an important demand in poultry production. With the increasing concerns on this issue, greater attention paid to alternatives to antibiotics for organic meat and egg production has led to a great demand. This study was conducted with view to assessing the possible role of M. oleifera as a natural feed supplement in poultry ration. Various scientific findings and published research articles were considered concerning issues including the study background, objectives, major findings, and conclusions of the review. M oleifera is known as a miracle tree because of its wealthy resource of various nutrients with high biological values. M. oleifera has been used as a growth promoter, immune enhancer, antioxidant, and has a hypo-cholesterol effect on chickens. It has both nutritional and therapeutic values. However, there is still much confusion in past published articles involving the major roles of M. oleifera in production performance and health status of chickens. Taking this into account, the present study highlights an outline of the experimental uses of M. oleifera on growth performance, egg production performance, egg quality, and health status in broilers and laying hens justified with the past findings to the present. The knowledge gaps from the past studies are considered, and the feasibility of M. oleifera in poultry ration is suggested. The findings have motivated further study on M. oleifera to find out the most active ingredients and their optimal doses in both broiler and laying hen rations. Finally, the present study highlights that supplementation of M. oleifera may play a role in the immunity, sound health, and production performance in poultry.
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Allgemein (full text)
Agriculture 2018, 8(9), 145; https://doi.org/10.3390/agriculture8090145
Moringa oleifera L. (moringa) is known as one of the most useful multipurpose plants. It can be effectively utilized as a natural biopesticide and inhibitor of several plant pathogens. Thus, it can be included in integrated pest management strategies. Moringa and its products have different uses in many agricultural systems. The use of moringa as a crop enhancer is an eco-friendly way of improving crop yields at the lowest possible cost. This inexpensive increase in productivity can contribute to meeting some of the food needs in some parts of the world as the global population increases and poverty rates rise. One of the most important characteristics of moringa is that it has high biological and nutritional values and can be used as animal feed, green fertilizer, medicine, biopesticide and in seed production. Moringa has been characterized as a potentially useful animal feed owing to its high content of protein, carotenoids, several minerals and vitamins (such as iron and ascorbic acid) and certain phytochemicals (kaempferitrin, isoquercitrin, rhamnetin, kaempferol and quercetin). This review aims to provide more knowledge about the nature, nutritional value, phytochemicals and uses of Moringa oleifera as a promising material in the fields of soil and plant management, water treatment, as well as animal and poultry production.
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Allgemein (full text)
Moringa oleifera Lam. A miraculous medicinal plant: Review
Abstract: The purpose of the review is to provide general information and research studies of Moringa oleifera to researchers to search the new phyto-constituent or molecules from the plant that may be valuable for therapeutic purpose. M. oleifera is a popular medicinal and vegetable plant. It is commonly distributed in different part of world. It has many therapeutic effects. It is also well known for its nutritional value. It contains many minerals such as calcium, potassium, magnesium, vitamin A, and C, beta-carotene quercetin and kaempferol. It possesses several pharmacological activities such as antioxidant, anti-inflammatory, cardioprotective, antibacterial, antifungal and gastroprotective activity. The present review provides the information regarding the phytoconstituents and pharmacological potential of the plant.
Diabetes
Diabetes (full text)
Nutrients. 2020 Jul 10;12(7):E2050. doi: 10.3390/nu12072050.
Moringa oleifera (MO) is a multipurpose plant consumed as food and known for its medicinal uses, among others. Leaves, seeds and pods are the main parts used as food or food supplements. Nutritionally rich and with a high polyphenol content in the form of phenolic acids, flavonoids and glucosinolates, MO has been shown to exert numerous in vitro activities and in vivo effects, including hypoglycemic activity. A systematic search was carried out in the PubMed database and reference lists on the effects of MO on glucose metabolism. Thirty-three animal studies and eight human studies were included. Water and organic solvent extracts of leaves and, secondly, seeds, have been extensively assayed in animal models, showing the hypoglycemic effect, both under acute conditions and in long-term administrations and also prevention of other metabolic changes and complications associated to the hyperglycemic status. In humans, clinical trials are scarce, with variable designs and testing mainly dry leaf powder alone or mixed with other foods or MO aqueous preparations. Although the reported results are encouraging, especially those from postprandial studies, more human studies are certainly needed with more stringent inclusion criteria and a sufficient number of diabetic or prediabetic subjects. Moreover, trying to quantify the bioactive substances administered with the experimental material tested would facilitate comparison between studies.
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Diabetes (abstract)
The effects of Moringa oleifera on blood glucose levels: A scoping review of the literature
Frederick S Owens 3rd 1, Oluwabunmi Dada 2, John W Cyrus 3, Oreoluwa O Adedoyin 4, Georges Adunlin 5
Abstract
Diabetes is an increasingly problematic health concern in the United States. Moringa oleifera (M. oleifera) has been suggested as medication in the prevention or treatment of diabetes, but there is no convincing evidence of a causal relation between moringa and decreased blood sugar levels in humans. The purpose of this scoping review is to examine the effects of Moringa oleifera on blood glucose levels in rats and humans. A search of Scopus, Ovid Medline, Ovid Embase, IPA, and Web of Science and manual searching of bibliographies were performed for peer-reviewed English articles published between May 1, 2008 and May 1, 2018. This review included thirty studies. Out of seven human studies, five found that M. oleifera significantly reduced blood glucose levels in diabetic patients. Out of twenty-three animal studies, twenty-one found that administration of M. oleifera led to a statistically significant decrease in animal blood glucose levels. In human studies, moringa was mostly administered in a powdered leaf form, while in animal studies it was frequently administered to as an aqueous or ethanol-based extract. The review found statistical evidence that moringa decreased blood glucose; the evidence is not strong enough to recommend it as the default treatment for people with diabetes.
Keywords: Antidiabetic; Aqueous; Blood glucose; Ethanol; Moringa oleifera.
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Diabetes (full text)
Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies.
Nutrients. 2019 Dec 2;11(12):2907. doi: 10.3390/nu11122907.
Diabetes and related neurological complications are serious worldwide public health problems. The increasing number of affected individuals make it necessary to implement novel nutritional and therapeutic interventions. The tree Moringa oleifera (MO) has been used as a food source and for traditional medicine purposes due to possible antihyperglycemic, antioxidant, anti-inflammatory, and lipid regulating properties. These properties may be explained by the presence of numerous phytochemicals in the leaves, fruits, roots and, oil of the tree. The evidence for acute antihyperglycemic effects of MO extract on diabetic animal models seems to be robust, but more chronic and long-term studies are needed. In contrast, the hypoglycemic effects of MO on humans are not as clear. The scarce number of human studies, together with a diverse range of methodologies and MO doses, may explain this. In addition, evidence regarding changes in insulin levels due to MO intervention is ambiguous, both in animal and human studies. Therefore, more structured studies are needed to clarify if MO has an effect on insulin levels or activity.
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Diabetes (abstract)
Moringa oleifera and glycemic control: A review of current evidence and possible mechanisms.
Phytother Res. 2019 Nov;33(11):2841-2848. doi: 10.1002/ptr.6473. Epub 2019 Aug 19.
Maintaining glycemic control in diabetes and prediabetes is necessary to prevent many health complications and mortality. Although different hypoglycemic drugs are used for this purpose, there is still a growing interest in the use of medicinal plants due to their low price, easy availability, and fewer or no side effects. Moringa (Moringa oleifera Lam.) is a medicinal plant that has been traditionally used in the management of diabetes. This review aims to present the existing literature published until February 2019 on the role of moringa leaves in glycemia and their physiological mechanisms. In the conducted studies, moringa leaves have shown to reduce glycemia, without causing any adverse effects. The proposed mechanisms for reducing glycemia include inhibition of α-amylase and α-glucosidase activities, increased glucose uptake in the muscles and liver, inhibition of glucose uptake from the intestine, decreased gluconeogenesis in the liver, and increased insulin secretion and sensitivity. However, these studies are limited in numbers and mostly conducted in animals, in vitro and in vivo. Therefore, long-term human studies are required to determine the hypoglycemic effect of moringa leaves, their physiological mechanisms, active ingredients, and safety. Overall, this review provides evidence that moringa leaves have the possibility to be used as a glycemic control agent in diabetes and prediabetes.
Unterernährung
Unterernährung (abstract)
J Food Prot. 2019 Feb 27:513-521. doi: 10.4315/0362-028X.JFP-18-252. [Epub ahead of print]
This qualitative risk assessment (QRA) was conducted to estimate the microbiological risk associated with the consumption of Moringa oleifera leaf powder (MLP) by infants and children ages 6 to 23 months to prevent or treat undernutrition in Siem Reap, Cambodia, and Madhya Pradesh, India. This QRA follows the Codex Alimentarius Commission principles and guidelines for risk assessment and takes into account all known microbial hazards that are associated with MLP. A comprehensive literature search was carried out for foodborne pathogens isolated from MLP and other dried foods of similar consistency, such as dried herbs and spices and flour. From this literature search, the following pathogens were identified and considered for this microbiological QRA: Bacillus cereus, Escherichia coli, Campylobacter spp., Clostridium perfringens, Cronobacter spp., Listeria monocytogenes, Salmonella spp., and Staphylococcus aureus. Results suggest that when cereal slurry (porridge) fortified with MLP is boiled (a rolling boil for 5 min) prior to consumption, the food safety risk to undernourished infants and children of B. cereus, C. perfringens type A, Cronobacter, enterohemorrhagic E. coli, L. monocytogenes, Salmonella spp., and S. aureus is low to moderate, with only a moderate to serious risk posed by C. perfringens type C. However, when the fortified porridge is not boiled before consumption, the food safety risk is increased for all of the evaluated pathogens. Overall, the QRA suggests that MLP presents a risk to undernourished infants and children. However, this risk can be mitigated when the powder is stored under the appropriate conditions to ensure there is no ingress of moisture and then processed in a hygienic manner to reduce contamination and/or cross-contamination by following hazard analysis critical control point or similar procedures (even in a home setting) including a heat treatment, i.e., boiling, to further reduce microbial hazards.
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Unterernährung / Vitaminmangel
Vitaminmangel (abstract)
Moringa Oleifera in Malnutrition: A Comprehensive Review.
Curr Drug Discov Technol. 2019 Nov 5. doi: 10.2174/1570163816666191105162722. Online ahead of print.
Nutritional deficiency is a major concern in developing countries resulting in serious health consequences like mental and physical growth retardation. Moringa oleifera(Moringa), a nutritious plantgrowing in tropical regions of developing countries, is a candidate for overcoming nutritional deficiency. Moringa leaves are rich in protein including Sulphur containing amino acids.It contains high amounts of vitamin C than oranges, higher concentration of vitamin A than carrots, higher calcium content than milk and more potassium than bananas. Moreover, there is 9 times more iron in moringa than spinach, 4 times more fiber than oat. This review is enlightening and exploring the nutritional diversification of Moringa oleifera and other benefits which make it a better choice to use in our daily diet to combat the situation of malnutrition.
Krebs
Krebs (full text)
month: 12 year: 2018
Biomed Pharmacother. 2018 Dec;108:457-466. doi: 10.1016/j.biopha.2018.09.060. Epub 2018 Sep 18.
Moringa oleifera and their phytonanoparticles: Potential antiproliferative agents against cancer.
Cancer is classified as one of the leading causes of global mortality. It has affected millions of people, often with poor prognosis. Having severe side-effects with conventional chemotherapy, alternate drugs and therapies are actively being investigated. There is a need for innovative drug discovery and design as existing cancer therapies are costly and not readily available. Ayurveda and traditional medicine have utilised natural resources such as plants and trees as part of their regime to treat various illness and diseases with positive outcomes. One such tree is Moringa oleifera (MO). Almost all parts have shown to be effective against several ailments including cancer which was attributed to the bioactive constituents. Targeted therapies had led to the development of nanoparticles which are extremely effective in various biomedical applications due to their small size. Green synthesis of gold nanoparticles have great potential as naturally occurring plants and trees such as MO can be used in the synthesis process. The resultant gold phytonanoparticles are useful in cancer therapies with improved survival rates and quality of life. The review highlights the importance of MO in natural medicine, synthesis of phytonanoparticles and the fundamental role as a potential antiproliferative agent against cancer.
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Krebs (full text)
The In Vitro and In Vivo Anticancer Properties of Moringa oleifera.
Evid Based Complement Alternat Med. 2018 Nov 14;2018:1071243. doi: 10.1155/2018/1071243. eCollection 2018.
Moringa oleifera, a fast-growing deciduous tree that is widely cultivated in tropical and subtropical regions of the world, is well known for its abundant uses. The tree is a source of food, shelter, and traditional medicine for many people, especially in developing countries. Many studies have been conducted to evaluate the various claims of traditional medicine practitioners that the moringa tree can improve health and treat various diseases. The tree has a high nutritional profile, especially the nutrient rich leaves. Some reports also support the use of parts of the tree to reduce blood sugar and cholesterol levels. These attractive properties have led researchers to look for other novel uses for the moringa tree, especially as a source of anticancer drugs. Researchers have tested extracts from various parts of the moringa tree both in vitro and in vivo on several types of cancers with varying success. This review explores the state of current research on the anticancer properties of M. oleifera.
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Krebs (full text)
Moringa oleifera Lam: Targeting Chemoprevention.
Asian Pac J Cancer Prev. 2016;17(8):3675-86.
Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as „murungai“ or „kelor“. Glucomoringin, a glucosinolate with from M. oleiferais a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and benefits. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxification, anti-inflammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there is promising evidence about M. oleifera in chemoprevention, extensive research needs to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera influence, which could be a good source to inhibit several major mechanisms involved in cancer development.
Oxidativer / nitrosativer Stress
Oxidativer / nitrosativer Stress (abstract)
month: (abstract)
07 / year: 2020
Mini Rev Med Chem. 2020 Jul 28. doi: 10.2174/1389557520999200728162453. Online ahead of print.
Moringa Oleifera: A Review of Its Occurrence, Pharmacological Importance and Oxidative stress.
Oxidative / nitrosative stress can be caused by excessive production of ROS and RNS with metabolic reactions that change balance in favor of oxidants in cases where oxidants increase and antioxidants decrease in organisms using oxygen. ROS and RNS react with several biological macromolecules in cell, such as carbohydrates, nucleic acids, lipids, and proteins, and alter their functions. Some natural antioxidants are constantly being researched for their benefits in terms of human health, which can strengthen the body’s antioxidant defense system and have the potential to scavenger free radicals. It is a well-known and practical strategy to prevent and / or treat diseases due to the consumption of more suitable fruits, herbs, spices and vegetables and the presence of bioactive antioxidant compounds. Moringa oleifera, a new and important one of these plants, has a wide range of bioactive compounds that can be obtained in different herbal structures such as leaves, seeds, stems and shells. It consists of bioactive molecules such as phenolic compounds, fats, fatty acids, carbohydrates, proteins, functional peptides, vitamins, minerals and essential amino acids as well as a number of glycosides and have great potential for use in various formulations in various health and food products. This review highlights the formation of MO, its importance in natural medicine, its pharmacological value, and its role as a possible anti-proliferative agent against cancer and its use in some diseases.
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Entzündung
Entzündung / Full Text
Int J Mol Sci. 2017 Jun 22;18(7). pii: E1330. doi: 10.3390/ijms18071330.
To investigate the mechanisms by which Moringa oleifera leaves (ML) modulate hepatic lipids, guinea pigs were allocated to either control (0% ML), 10% Low Moringa (LM) or 15% High Moringa (HM) diets with 0.25% dietary cholesterol to induce hepatic steatosis. After 6 weeks, guinea pigs were sacrificed and liver and plasma were collected to determine plasma lipids, hepatic lipids, cytokines and the expression of genes involved in hepatic cholesterol (CH) and triglyceride (TG) metabolism. There were no differences in plasma lipids among groups. A dose-response effect of ML was observed in hepatic lipids (CH and TG) with the lowest concentrations in the HM group (p < 0.001), consistent with histological evaluation of lipid droplets. Hepatic gene expression of diglyceride acyltransferase-2 and peroxisome proliferator activated receptor-γ, as well as protein concentrations interleukin (IL)-1β and interferon-γ, were lowest in the HM group (p < 0.005). Hepatic gene expression of cluster of differentiation-68 and sterol regulatory element binding protein-1c were 60% lower in both the LM and HM groups compared to controls (p < 0.01). This study demonstrates that ML may prevent hepatic steatosis by affecting gene expression related to hepatic lipids synthesis resulting in lower concentrations of cholesterol and triglycerides and reduced inflammation in the liver.
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Entzündung / Abstract
Entzündung / Abstract
Medicinal plants are increasingly being evaluated for the treatment of chronic disorders. This study was aimed at assessing anti-arthritic potential of Moringa oleifera (wild type). Different extracts of the plant leaves were prepared and evaluated for the presence and quantification of phytochemicals. The plant extracts were assessed for in vitro antioxidant activity by different methods followed by in vitro anti-inflammatory assays such as protein denaturation, membrane stabilization and anti-proteinase activities. The plant extracts were further assessed in Wistar rats by formaldehyde induced arthritis model at 150, 300 and 600 mg/kg dosage level. Chemical analysis showed that methanolic and aqueous extracts contained the highest total phenolic and flavonoid contents. Kaempferol, gallic acid, vanillic acid, coumaric acid and quercetin were detected and quantified in the plant extracts. It was found that the methanolic, aqueous and ethyl acetate extracts had exhibited the maximum in vitro antioxidant potential. These extracts also exhibited a decrease in protein denaturation, prevented lysis of red blood cell membranes and showed anti-proteinase activities. These extracts showed significant inhibition in paw inflammation and prevented arthritis induced anemia and weight loss in rats in dose dependent manner. The outcomes of this research indicated that all extracts of M. oleifera had exerted significant antioxidant and anti-arthritic potential in rats in dose dependent manner. Anti-arthritic activity of M. oleifera might be due to the scavenging of free radicals, inhibition of protein denaturation, membrane stabilization and anti-proteinase activity.
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Entzündung / Abstract
Quercetin alleviates inflammation after short-term treatment in high-fat-fed mice.
Food Funct. 2013 Jun;4(6):889-98. doi: 10.1039/c3fo30241e. Epub 2013 May 3.
Consumption of a high-fat diet (HFD) promotes reactive oxygen species (ROS) which ultimately trigger inflammation. The aim of this study was to investigate the role of Moringa oleifera leaf extract (MoLE) and its active component quercetin in preventing NF-κB-mediated inflammation raised by short-term HFD. Quercetin was found to be one of the major flavonoid components from HPLC of MoLE. Swiss mice were fed for 15 days on HFD, both with or without MoLE/quercetin. The antioxidant profile was estimated from liver homogenate. NF-κB and some relevant inflammatory markers were evaluated by immunoblotting, RT-PCR and ELISA. Significantly (P < 0.05) lower antioxidant profile and higher lipid peroxidation was found in HFD group compared to control (P < 0.05). Increased nuclear import of NF-κB and elevated expressions of pro-inflammatory markers were further manifestations in the HFD group. All these changes were reversed in the MoLE/quercetin-treated groups with significant improvement of antioxidant activity compared to the HFD group. MoLE was found to be rich in polyphenols and both MoLE and quercetin showed potent free radical and hydroxyl radical quenching activity. Thus, the present study concluded that short-term treatment with MoLE and its constituent quercetin prevent HFD-mediated inflammation in mice. … Read More
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Entzündung / Full Text
Mutmainnah Nurul , Achmad Muhammad Harun
Abstract: Introduction: Moringa plant is a plant that is spread throughout the region in Indonesia and has many benefits. Moringa oleifera L. plant is also known as the “miracle of tree” because almost all parts of the plant, from the leaves, bark, seeds, fruit of moringa to the roots are used by humans, especially as traditional medicine. Moringa has been proven effective as antibacterial and anti-inflammatory, for example in toothpaste, mouthwash, and root canal irrigation from chitosan. So this systematic review reviews some of the literature on the potential of moringa plants as antibacterial and antiinflammatory in the oral cavity. Methods: In this systematic review, article searches were conducted on Google Search and Pubmed. Studies published from 2011 to 2020. 104 articles were rated, including 104 articles from electronic databases, 0 from manual search. 96 records were screened, 63 records were excluded, 33 full-text articles were assessed for eligibility and 17 full-text articles were included. Result: There are 8 articles about antibacterial of Moringa oleifera and 10 articles about anti-inflammatory of Moringa oleifera. Conclusion: Based on 18 articles show that chitosan is very potential as a herbal plant that can be antibacterial and anti-inflammatory in the oral cavity.
Keywords: Moringa oleifera, Antibacterial, Anti-inflammatory, Oral cavity
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Entzündung / Abstract
Abstract
Lead (Pb) is an environmental toxicant; its consumption can induce renal deficits. In this study, we explored the possible protective efficiency of Moringa oleifera extract (MOE) against lead acetate (PbAc)-mediated reprotoxicity. Four experimental groups of seven rats each were used: control, PbAc, MOE, and MOE+PbAc groups. All groups were given their respective treatment for 4 weeks. PbAc impaired the oxidative/antioxidative balance in the renal tissue, as shown by the decreased antioxidant proteins (glutathione, glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase) and increased oxidants (lipid peroxidation and nitric oxide). Additionally, PbAc enhanced the progression of kidney inflammation by increasing tumor necrosis factor-alpha, interleukin-1 beta, and nuclear factor kappa B associated with upregulation of inducible nitric oxide synthase. Moreover, a dysregulation in the apoptotic-regulating proteins (Bax, caspase-3, and Bcl2) were recorded upon PbAc exposure. Remarkably, MOE oral administration restored redox homeostasis, suppressed the inflammatory and apoptotic responses in the kidney tissue. Our findings point out that MOE could be used as an alternative remedy to overcome the adverse effects of Pb exposure, which may be due to its potent antioxidant, anti-inflammatory, and anti-apoptotic effects.
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