Tier­fut­ter (nur Haus­säu­ge­tie­re)

Tier­fut­ter (abs­tract)

month: 01  / year: 2020

J Anim Phy­si­ol Anim Nutr (Berl). 2020 Jan;104(1):291–299.  doi: 10.1111/jpn.13224. Epub 2019 Oct 30.

Effect of Morin­ga olei­fe­ra sup­ple­men­ta­ti­on on pro­duc­tive per­for­mance, colo­s­trum com­po­si­ti­on and serum bio­che­mi­cal inde­xes of sow.

Morin­ga olei­fe­ra has been con­s­i­de­red as a poten­ti­al func­tio­nal feed or food, sin­ce it con­ta­ins mul­ti­ple com­pon­ents bene­fi­ci­al to ani­mal and human. Howe­ver, litt­le is known about the effects of Morin­ga olei­fe­ra sup­ple­men­ta­ti­on on pro­duc­tive per­for­man­ces in sows. In the cur­rent stu­dy, the results show­ed that die­ta­ry Morin­ga olei­fe­ra signi­fi­cant­ly decrea­sed the far­ro­wing length and the num­ber of still­born (p < .05), while had an increa­sing trend in the num­ber of live-born (0.05 < p < .10). Fur­ther­mo­re, 8% Morin­ga olei­fe­ra sup­ple­men­ta­ti­on signi­fi­cant­ly ele­va­ted pro­te­in levels in the colo­s­trum (p < .05); 4% Morin­ga olei­fe­ra lowed serum urea nitro­gen of sows after 90 days of gesta­ti­on (p < .05) and signi­fi­cant­ly decrea­sed serum glu­co­se on 10 days of lac­ta­ti­on (p < .05). Both groups show­ed signi­fi­cant ele­va­ti­on in serum T-AOC activi­ty (p < .05). The serum malon­di­al­de­hy­de (MDA) of sows decli­ned signi­fi­cant­ly in 4% Morin­ga olei­fe­ra addi­ti­on group (p < .05). 8% Morin­ga olei­fe­ra meal signi­fi­cant­ly ele­va­ted serum CAT activi­ty after 60 days of gesta­ti­on (p < .05), while decrea­sed the serum MDA level and increa­sed the serum GSH-Px activi­ty of sows at 10 days of lac­ta­ti­on (p < .05). Of piglets, both two dosa­ges of Morin­ga olei­fe­ra sup­ple­men­ta­ti­on essen­ti­al­ly redu­ced the serum urea nitro­gen (p < .05), and 4% Morin­ga olei­fe­ra meal increa­sed serum total pro­te­in (p < .05). In addi­ti­on, piglets that recei­ved 8% Morin­ga olei­fe­ra had the hig­hest serum CAT and SOD activi­ties among all groups (p < .05). The pre­sent stu­dy indi­ca­ted that Morin­ga olei­fe­ra sup­ple­men­ta­ti­on could enhan­ce the repro­duc­tion per­for­man­ces, ele­va­te pro­te­in levels in the colo­s­trum and impro­ve the serum anti­oxi­dant indi­ces in both sows and piglets.

Key­wor­ds: Morin­ga olei­fe­ra lea­ve meal; anti­oxi­dant; far­ro­wing length; sows.

 

Tier­fut­ter (full text)

Cur­rent Sta­tus and Poten­ti­al of Morin­ga olei­fe­ra Leaf as an Alter­na­ti­ve Pro­te­in Source for Ani­mal Feeds.

Front Vet Sci. 2020 Feb 26;7:53. doi: 10.3389/fvets.2020.00053. eCollec­tion 2020.

The increa­sed con­sump­ti­on of live­stock, poul­try, and fish pro­ducts in people’s diet threa­tens to dri­ve pro­duc­tion toward the use of more and more con­ven­tio­nal crops in ani­mal feeds. In this con­text, alle­via­ting the tigh­ten­ing grain crop sup­ply and ensu­ring the healt­hy deve­lop­ment of ani­mal hus­bandry through inno­va­tions in pro­te­in feed­s­tuff pro­duc­tion remain con­s­i­derable chal­len­ges. Morin­ga olei­fe­ra is a mira­cle tree spe­ci­es with abundant nut­ri­ents, high pro­te­in bio­lo­gi­cal value, and good fee­ding effect. As a new pro­te­in feed­s­tuff, M. olei­fe­ra has gre­at poten­ti­al in alle­via­ting the fee­ding cri­sis. Here, we review avail­ab­le lite­ra­tu­re regar­ding the cha­rac­te­ri­za­ti­on of M. olei­fe­ra in the field of ani­mal hus­bandry in terms of nut­ri­ent con­tent, diges­ti­on, and absorp­ti­on cha­rac­te­ris­tics, and fee­ding effects and pre­sent cur­rent chal­len­ges in using M. olei­fe­ra as ani­mal feed.

 

Tier­fut­ter (abs­tract)

Hor­mo­nal chan­ges, semen qua­li­ty and vari­an­ce in repro­duc­tive activi­ty out­co­mes of post puber­tal rab­bits fed Morin­ga olei­fe­ra Lam. leaf powder.

J Eth­no­phar­ma­col. 2018 Dec 26;233:80–86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]

ETHNOPHARMACOLOGICAL RELEVANCE:
Morin­ga olei­fe­ra Lam. (Moring­aceae) is an important plant based stap­le food, known for its nut­ri­tio­nal and medi­c­inal value and is usual­ly pre­scri­bed by her­bal prac­titio­ners in Nige­ria and in other tro­pi­cal coun­tries for the tre­at­ment of male infer­ti­li­ty pro­blems and repro­duc­tive disea­ses in fema­les. Alt­hough the aphro­di­siac pro­per­ties and fer­ti­li­ty enhan­ce­ment poten­ti­al in males have been repor­ted, the under­ly­ing mecha­nisms for the activi­ty remain unclear. In this stu­dy, we inves­ti­ga­ted the influ­ence of sup­ple­men­ting the diet with M. olei­fe­ra Lam. leaf powder on repro­duc­tive hor­mo­nes and semen qua­li­ty of New Zea­land White (NZW) rab­bits.
MATERIALS AND METHODS:
Thir­ty-two (32) NZW rab­bits of 50:50 ratio bucks to does, were ran­dom­ly dis­tri­bu­t­ed to four tre­at­ment groups (n = 4 bucks, n = 4 does per group). Gra­ded levels (0, 5, 10 and 15 g/kg) of M. olei­fe­ra Lam. leaf powder was incorpo­ra­ted into rab­bit gro­wers pel­let. The does and bucks were hou­sed sepa­r­a­te­ly in hut­ches and shel­te­red under the same envi­ron­men­tal con­di­ti­ons with free access to their respec­tive tre­at­ment diets for a peri­od of 12 weeks.
RESULTS:
In fema­le rab­bits, tre­at­ment revea­led signi­fi­cant (P < 0.05) dose-depen­dent reduc­tion in the con­cen­tra­ti­on of serum FSH, LH and oestro­gen. While in con­trast the hig­hest dose of leaf powder signi­fi­cant­ly (P < 0.05) increa­sed pro­ges­te­ro­ne and pro­lac­tin con­cen­tra­ti­ons remai­ned unaf­fec­ted. On the other hand, the con­cen­tra­ti­on of FSH and LH in bucks was signi­fi­cant­ly (P < 0.05) increa­sed in tre­at­ment groups com­pa­red to the con­trol group. Serum tes­to­ste­ro­ne con­cen­tra­ti­ons were signi­fi­cant­ly lower in the 5 and 10 g/kg tre­at­ment groups. Semen volu­me, sperm count and moti­li­ty were signi­fi­cant­ly impro­ved in a dose depen­dent man­ner with increa­sing amounts of M. olei­fe­ra Lam. leaf powder in the diet. CONCLUSIONS: We con­clu­de that M. olei­fe­ra Lam. leaf powder sup­ple­men­ta­ti­on to the diet was more bene­fi­ci­al to male rab­bit fer­ti­li­ty than the fema­le, whe­re it ten­ded to have a nega­ti­ve impact through the hypo­tha­l­a­mic-pitui­ta­ry-gona­dal axis. Howe­ver, with the vary­ing impact of M. olei­fe­ra Lam. leaf powder on the hypo­tha­l­a­mic-pitui­ta­ry-gona­dal axis of male and fema­le ani­mals, fur­t­her inves­ti­ga­ti­on is necessa­ry to deter­mi­ne the mecha­nism through which it ope­ra­tes.

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Milch­bil­dung beim Men­schen (full text)

Morin­ga.

Drugs and Lac­ta­ti­on Data­ba­se (Lact­Med) [Inter­net]. Bethes­da (MD): Natio­nal Libra­ry of Medi­ci­ne (US); 2018.

Morin­ga (Morin­ga olei­fe­ra) lea­ves con­tain vit­amins, mine­rals, and essen­ti­al ami­no acids as well as a num­ber of gly­co­si­des. It is used as a galac­togo­gue in Asia,[1] par­ti­cu­lar­ly in the Phil­ip­pi­nes whe­re it is cal­led malung­gay. Two small stu­dies from the Phil­ip­pi­nes indi­ca­te that it might have some activi­ty as a galac­togo­gue in mothers of pre­term infants.[2][3] Galac­togo­gues should never replace eva­lua­ti­on and coun­se­ling on modi­fia­ble fac­tors that affect milk production.[4] Morin­ga olei­fe­ra lea­ves are wide­ly used as a food and medi­ci­ne in Asia and Afri­ca and one small stu­dy found no adver­se effects in nur­sing mothers who inge­sted morin­ga leaves.[2] No data exist on the safe­ty of Morin­ga in nur­sing infants. Die­ta­ry sup­ple­ments do not requi­re exten­si­ve pre-mar­ke­ting appro­val from the U.S. Food and Drug Admi­nis­tra­ti­on. Manu­fac­tu­rers are respon­si­ble to ensu­re the safe­ty, but do not need to pro­ve the safe­ty and effec­tiveness of die­ta­ry sup­ple­ments befo­re they are mar­ke­ted. Die­ta­ry sup­ple­ments may con­tain mul­ti­ple ingre­dients, and dif­fe­ren­ces are often found bet­ween labe­led and actu­al ingre­dients or their amounts. A manu­fac­tu­rer may con­tract with an inde­pen­dent orga­ni­za­ti­on to veri­fy the qua­li­ty of a pro­duct or its ingre­dients, but that does not cer­ti­fy the safe­ty or effec­tiveness of a pro­duct. Becau­se of the above issu­es, cli­ni­cal tes­ting results on one pro­duct may not be app­li­ca­ble to other pro­ducts. More detail­ed infor­ma­ti­on about die­ta­ry sup­ple­ments is avail­ab­le else­whe­re on the Lact­Med Web site.

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Tier­fut­ter (full text)

Effect of Fee­ding Morin­ga (Morin­ga olei­fe­ra) as Green Fod­der on Feed Inta­ke, Milk Yield, Micro­bi­al Pro­te­in Syn­the­sis and Blood Pro­fi­le in Cross­bred Cows

Abs­tract

To eva­lua­te the effect of fee­ding Morin­ga (Morin­ga olei­fe­ra) as green fod­der on feed inta­ke, milk yield, micro­bi­al pro­te­in syn­the­sis, and blood pro­fi­le, a stu­dy was con­duc­ted on twen­ty lac­ta­ting cross­bred cows in Anand dis­trict of Guja­rat. Cows were divi­ded into two groups of ten each, based on milk yield (9–10 kg/d), fat con­tent (3.5–3.8%) and sta­ge of lac­ta­ti­on (av. 60 days in milk). Cows in con­trol group were fed 3.0 kg each chaf­fed wheat and pul­se straw, 15.0 kg green hybrid Napier grass and 5.0 kg catt­le feed (23.0% CP; 4.0% EE), Whe­re­as, cows in expe­ri­men­tal group were fed 15.0 kg Morin­ga green fod­der (by repla­cing 15.0 kg hybrid Napier) for 90 days. Nut­ri­ent requi­re­ment was adjus­ted by redu­cing quan­ti­ty of catt­le feed (3.5 kg). Stu­dy revea­led that milk yield and fat con­tent increa­sed

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Tier­fut­ter (full text)

Peri­par­tu­ri­ent anti­oxi­dant enzy­mes, haema­to­lo­gi­cal pro­fi­le and milk pro­duc­tion of dai­ry cows sup­ple­men­ted with Morin­ga olei­fe­ra leaf meal

ABSTRACT

This stu­dy eva­lua­ted the effects of fee­ding tran­si­ti­on Hol­stein cows with Morin­ga olei­fe­ra leaf meal (MOLM) on anti­oxi­dant enzy­mes, haema­to­lo­gi­cal pro­fi­le and milk pro­duc­tion. Forty-eight pregnant Hol­stein cows recei­ved increa­sing levels of Morin­ga olei­fe­ra leaf meal (MOLM) at M0: Con­trol; M30: 8.33 g MOLM /100 kg BW and M60: 16.66 g MOLM /100 kg BW. Blood sam­ples were collec­ted to deter­mi­ne haema­to­lo­gy, anti­oxi­dant enzy­mes and bio­che­mi­stry. Milk was sam­pled to deter­mi­ne yield, com­po­si­ti­on, anti­oxi­dant sta­tus (MTAC) and soma­tic cell count (SCC). White blood cells (WBC) and red blood cells (RBC) were high in M60 group than tho­se in M0 (P = 0.02) and (P = 0.03) respec­tively. Cows in M60 tre­at­ment group had hig­her (P < 0.01) serum super­oxi­de dis­mu­ta­se (SOD) and total anti­oxi­dant capa­ci­ty (STAC) than M30 and M0 tre­at­ment groups. Alt­hough, milk yield and body weight were not (P > 0.05) affec­ted by tre­at­ment, cows in M60 group were recor­ded with the hig­hest milk fat (P < 0.01), pro­te­in (P = 0.01) and MTAC (P < 0.01) values. In con­clu­si­on, sup­ple­men­ting MOLM (M60) to tran­si­ti­on dai­ry cows was shown to impro­ve blood bio­che­mi­stry, anti­oxi­dant sta­tus and udder health. Moreo­ver, milk com­po­si­ti­on and milk anti­oxi­dant capa­ci­ty but not milk yield impro­ved with sup­ple­men­ta­ti­on of MOLM (M60).

 

Tier­fut­ter / Abs­tract

Food Res Int. 2018 Apr;106:317–334. doi: 10.1016/j.foodres.2017.12.079. Epub 2018 Jan 4.

Mul­ti-func­tio­nal app­li­ca­ti­on of Morin­ga olei­fe­ra Lam. in nut­ri­ti­on and ani­mal food pro­ducts: A review.

Abs­tract

Rese­arch on the use of various parts of the Morin­ga olei­fe­ra Lam. plant (M. olei­fe­ra) as a nut­ri­tio­nal and neu­traceuti­cal resour­ce for human and ani­mal diets has increa­sed in recent years, emana­ting from the widespread use of the plant in tra­di­tio­nal cui­sines and medi­c­inal reme­di­es in several regi­ons of the world. Ana­ly­ti­cal stu­dies have iden­ti­fied M. olei­fe­ra as an important source of essen­ti­al nut­ri­ents; rich in pro­te­in, essen­ti­al ami­no acids, mine­rals, and vit­amins, with a rela­tively low amount of anti­nut­ri­ents. It is also a rich source of other bio active com­pounds inclu­ding fla­vo­no­ids and phe­n­o­lic com­pounds; with several stu­dies detailing demons­tra­ted in vitro and in vivo func­tio­nal pro­per­ties, most sub­stan­ti­al­ly, anti­oxi­dant activi­ties. Morin­ga olei­fe­ra con­sump­ti­on has been repor­ted to impro­ve the health sta­tus, feed con­ver­si­on effi­ci­en­cy, growth per­for­mance and pro­duct qua­li­ty of several live­stock spe­ci­es, at die­ta­ry inclu­si­on rates gene­ral­ly not excee­ding 5% of total dry mat­ter inta­ke. Forti­fi­ca­ti­on of pro­ces­sed foods with M. olei­fe­ra has been repor­ted to increa­se nut­ri­tio­nal value, some orga­n­olep­tic pro­per­ties, oxi­da­ti­ve sta­bi­li­ty and pro­duct shelf life; with a nota­ble need for fur­t­her ana­ly­ti­cal and con­su­mer stu­dies in the deve­lop­ment of the­se pro­ducts. The­re is a pau­ci­ty of lite­ra­tu­re detailing cli­ni­cal stu­dies, nut­ri­ent bio­avai­la­bi­li­ty, toxi­ci­ty and the mode of action of the bioac­tive com­pounds to which the health claims asso­cia­ted with M. olei­fe­ra con­sump­ti­on are attri­bu­t­ed. Many of the­se are not yet ful­ly unders­tood; the­re­fo­re more rese­arch in the­se are­as is requi­red in order to ful­ly uti­li­ze the poten­ti­al bene­fits of this plant in human and live­stock nut­ri­ti­on.

Key­wor­ds: Forti­fi­ca­ti­on; Func­tio­nal bio-com­pounds; Live­stock pro­duc­tion; Morin­ga olei­fe­ra; Neu­traceuti­cals; Phy­to­che­mi­cals.

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Tier­fut­ter / Abs­tract

month: 12     year: 2018

J Eth­no­phar­ma­col. 2018 Dec 26;233:80–86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]

Hor­mo­nal chan­ges, semen qua­li­ty and vari­an­ce in repro­duc­tive activi­ty out­co­mes of post puber­tal rab­bits fed Morin­ga olei­fe­ra Lam. leaf powder.

Abs­tract

J Eth­no­phar­ma­col. 2018 Dec 26;233:80–86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]

ETHNOPHARMACOLOGICAL RELEVANCE:
Morin­ga olei­fe­ra Lam. (Moring­aceae) is an important plant based stap­le food, known for its nut­ri­tio­nal and medi­c­inal value and is usual­ly pre­scri­bed by her­bal prac­titio­ners in Nige­ria and in other tro­pi­cal coun­tries for the tre­at­ment of male infer­ti­li­ty pro­blems and repro­duc­tive disea­ses in fema­les. Alt­hough the aphro­di­siac pro­per­ties and fer­ti­li­ty enhan­ce­ment poten­ti­al in males have been repor­ted, the under­ly­ing mecha­nisms for the activi­ty remain unclear. In this stu­dy, we inves­ti­ga­ted the influ­ence of sup­ple­men­ting the diet with M. olei­fe­ra Lam. leaf powder on repro­duc­tive hor­mo­nes and semen qua­li­ty of New Zea­land White (NZW) rab­bits.
MATERIALS AND METHODS:
Thir­ty-two (32) NZW rab­bits of 50:50 ratio bucks to does, were ran­dom­ly dis­tri­bu­t­ed to four tre­at­ment groups (n = 4 bucks, n = 4 does per group). Gra­ded levels (0, 5, 10 and 15 g/kg) of M. olei­fe­ra Lam. leaf powder was incorpo­ra­ted into rab­bit gro­wers pel­let. The does and bucks were hou­sed sepa­r­a­te­ly in hut­ches and shel­te­red under the same envi­ron­men­tal con­di­ti­ons with free access to their respec­tive tre­at­ment diets for a peri­od of 12 weeks.
RESULTS:
In fema­le rab­bits, tre­at­ment revea­led signi­fi­cant (P < 0.05) dose-depen­dent reduc­tion in the con­cen­tra­ti­on of serum FSH, LH and oestro­gen. While in con­trast the hig­hest dose of leaf powder signi­fi­cant­ly (P < 0.05) increa­sed pro­ges­te­ro­ne and pro­lac­tin con­cen­tra­ti­ons remai­ned unaf­fec­ted. On the other hand, the con­cen­tra­ti­on of FSH and LH in bucks was signi­fi­cant­ly (P < 0.05) increa­sed in tre­at­ment groups com­pa­red to the con­trol group. Serum tes­to­ste­ro­ne con­cen­tra­ti­ons were signi­fi­cant­ly lower in the 5 and 10 g/kg tre­at­ment groups. Semen volu­me, sperm count and moti­li­ty were signi­fi­cant­ly impro­ved in a dose depen­dent man­ner with increa­sing amounts of M. olei­fe­ra Lam. leaf powder in the diet.
CONCLUSIONS:
We con­clu­de that M. olei­fe­ra Lam. leaf powder sup­ple­men­ta­ti­on to the diet was more bene­fi­ci­al to male rab­bit fer­ti­li­ty than the fema­le, whe­re it ten­ded to have a nega­ti­ve impact through the hypo­tha­l­a­mic-pitui­ta­ry-gona­dal axis. Howe­ver, with the vary­ing impact of M. olei­fe­ra Lam. leaf powder on the hypo­tha­l­a­mic-pitui­ta­ry-gona­dal axis of male and fema­le ani­mals, fur­t­her inves­ti­ga­ti­on is necessa­ry to deter­mi­ne the mecha­nism through which it ope­ra­tes.

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Tier­fut­ter / Abs­tract

month: 05     year: 2018

Ani­mal. 2018 May;12(5):964–972. doi: 10.1017/S1751731117002336. Epub 2017 Oct 9.

Effects of repla­ce­ment of Morin­ga olei­fe­ra for ber­seem clover in the diets of Nubi­an goats on feed uti­li­sa­ti­on, and milk yield, com­po­si­ti­on and fat­ty acid pro­fi­le.

Repla­ce­ment of con­ven­tio­nal feed­s­tuffs with cheap non-con­ven­tio­nal ingre­dients may impro­ve live­stock per­for­mance and the qua­li­ty of their pro­ducts, par­ti­cu­lar­ly milk. The stu­dy con­s­i­de­red the effects of Morin­ga olei­fe­ra (MO) folia­ge in repla­ce­ment of ber­seem clover (BC) on feed uti­li­sa­ti­on and lac­ta­tio­nal per­for­mance in Nubi­an goats. A total of 16 lac­ta­ting Nubi­an does, weig­hing 36.2±0.8 kg, were ran­dom­ly assi­gned to four expe­ri­men­tal tre­at­ments con­tai­ning 0, 125, 250 and 375 g of MO per kg diet to replace 0 (M0), 25 (M25), 50 (M50) and 75% (M75) of BC (on dry mat­ter (DM) basis) in a qua­dru­pli­ca­ted 4×4 Latin squa­re design. The MO diets increa­sed (P<0.01) feed inta­ke and nut­ri­ent diges­ti­bi­li­ty. Fee­ding MO diets impro­ved (P<0.01) rumi­nal vola­ti­le fat­ty acids, ace­ta­te and pro­pio­na­te but redu­ced (P<0.01) vale­ra­te and iso-buty­ra­te. Morin­ga diets increa­sed (P<0.01) serum total pro­te­in, albu­min and glu­co­se but decrea­sed (P<0.05) cho­le­ste­rol and tri­gly­ce­rides. Milk yield and ener­gy cor­rec­ted milk, and milk total solids, fat and ener­gy con­tent were increa­sed (P<0.01) in MO diets. Yiel­ds of milk com­pon­ents and ener­gy were grea­ter (P<0.05) for MO diets than for con­trol diet. Milk total satu­ra­ted fat­ty acids and ath­ro­ge­ni­ci­ty index were lower (P<0.01), and unsa­tu­ra­ted fat­ty acids, con­ju­ga­ted fat­ty acids and UFA/SFA ratio hig­her (P<0.05) for MO diets. It is con­clu­ded that fee­ding MO to replace 75% DM of BC impro­ved feed uti­li­sa­ti­on, rumi­nal fer­men­ta­ti­on, and milk yield and qua­li­ty in lac­ta­ting Nubi­an goats.

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Tier­fut­ter / Abs­tract

month: 02     year: 2018

J Anim Phy­si­ol Anim Nutr (Berl). 2018 Feb;102(1):194–203. doi: 10.1111/jpn.12678. Epub 2017 Jun 12.

Effects of Morin­ga olei­fe­ra lea­ves as a sub­sti­tu­te for alfal­fa meal on nut­ri­ent diges­ti­bi­li­ty, growth per­for­mance, car­cass trait, meat qua­li­ty, anti­oxi­dant capa­ci­ty and bio­che­mi­cal para­me­ters of rab­bits.

This con­tri­bu­ti­on reports the effects of Morin­ga olei­fe­ra lea­ves (MOLs) meal on the growth per­for­man­ces, nut­ri­ent diges­ti­bi­li­ty, car­cass trait, meat qua­li­ty, anti­oxi­dant capa­ci­ty and bio­che­mi­cal para­me­ters of gro­wing New Zea­land white rab­bits. The MOL was sub­sti­tu­ted for alfal­fa meal at levels of 0, 10%, 20% and 30% to obtain respec­tive diets MOL0, MOL10, MOL20 and MOL30. Each tre­at­ment was repli­ca­ted five times with 10 rab­bits per repli­ca­te. Results show­ed the average dai­ly weight gain (ADWG) and feed con­ver­si­on ratio (FCR) of rab­bits fed MOL20 diet were signi­fi­cant­ly bet­ter (p < 0.05) than tho­se of other three die­ta­ry groups. Liver and spleen index of rab­bits fed MOL20 and MOL30 diets was signi­fi­cant­ly hig­her (p < 0.05) than that of the groups fed with lower M. olei­fe­ra lea­ves (MOL0, MOL10). The meat drip loss of rab­bits fed with diet MOL10 was signi­fi­cant­ly lower (p < 0.05) than that of rab­bits fed other diets. All rab­bits fed MOL die­ta­ry groups had lower (p < 0.05) she­ar force of lon­gis­si­mus dor­si than the group without M. olei­fe­ra lea­ves. No signi­fi­cant dif­fe­ren­ces were found in the diges­ti­bi­li­ty of cru­de fib­re (CF), cru­de fat (EE), ash, cru­de pro­te­in (CP) and nitro­gen-free extract (NFE) among the die­ta­ry groups. Morin­ga olei­fe­ra lea­ves also have a signi­fi­cant impact on serum albu­min (ALB), low-den­si­ty lipo­pro­te­in cho­le­ste­rol (LDLC), triiodo­thy­ro­xi­ne (T3 ) and tetrai­odo­thy­ro­xi­ne (T4 ) values and the activi­ty of super­oxi­de dis­mu­ta­se (SOD) and cata­la­se (CAT) in serum and liver. The results indi­ca­ted that M. olei­fe­ra lea­ves could be deve­lo­ped as a good feed source, and it not only could sub­sti­tu­te for alfal­fa meal well but also has a signi­fi­cant effect on growth per­for­mance, meat qua­li­ty, anti­oxi­dant and bio­che­mi­cal para­me­ters of rab­bits.

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month: 12     year: 2017

Trop Anim Health Prod. 2017 Dec;49(8):1685–1688. doi: 10.1007/s11250-017‑1377-6. Epub 2017 Aug 13.

Effect of feed restric­tion on inta­ke of Morin­ga olei­fe­ra and Leu­cae­na leu­coce­pha­la and growth per­for­mance of rab­bits.

Two expe­ri­ments were con­duc­ted to eva­lua­te the effect of feed restric­tion on inta­ke of Morin­ga oleifera(MO) or Leu­cae­na leu­coce­pha­la (LL) and growth of rab­bits. In expe­ri­ment one, 45 rab­bits (male and fema­le) weig­hing 1.18 ± 0.15 kg were used. They were ran­dom­ly dis­tri­bu­t­ed to three feed restric­tion tre­at­ments (20, 30, and 40%) with 15 rab­bits each (9 fema­les and 6 males) and they were offe­red M. olei­fe­ra (MO) ad libi­tum. In expe­ri­ment two, 45 gro­wing male rab­bits weig­hing 0.63 ± 0.113 kg were used. They were ran­dom­ly assi­gned to 0, 20, and 30% feed restric­tion diets, and they have free access to L. leu­coce­pha­la (LL). Inta­ke of MO increa­sed (P < 0.05) con­for­ming feed restric­tion increa­sed (40.6, 52.9, and 55.2 g/day of MO for 20, 30, and 40%, respec­tively). Dai­ly live­weight gain and feed con­ver­si­on did not dif­fer (P > 0.05), and eco­no­mic effi­ci­en­cy was simi­lar among tre­at­ments. Con­sump­ti­on of LL increa­sed (P < 0.05) in rab­bits under the 30% restric­tion tre­at­ment in com­pa­ri­son to that of rab­bits restric­ted 20% (46.0 and 44.4 g/day, respec­tively). Total feed inta­ke (LL + feed) was hig­hest in 20% restric­ted rab­bits (108.0, 100.8, and 93.2 g/day for 20, 30, and 0%, respec­tively). Dai­ly live­weight gain and feed con­ver­si­on were not affec­ted by feed restric­tion (P > 0.05). Eco­no­mic effi­ci­en­cy impro­ved twice in feed-restric­ted rab­bits (2.0 and 2.3 for 20 and 30%, respec­tively) in con­trast to that of the con­trol 0% group (1.1). The results sug­gest that rab­bits restric­ted up to 30% and sup­ple­men­ted with eit­her MO or LL did not affect growth per­for­mance and redu­ced feed cost.

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[PDF] Impact of Die­ta­ry Sup­ple­men­ta­ti­on with Morin­ga olei­fe­ra Lea­ves on Per­for­mance, Meat Cha­rac­te­ris­tics, Oxi­da­ti­ve Sta­bi­li­ty, and Fat­ty Acid Pro­fi­le in Gro­wing Rab­bits

S Selim, MF Selei­man, MM Hassan, AA Saleh… — Ani­mals, 2021

Simp­le Sum­ma­ry: Rab­bit meat is most­ly pre­fer­red by con­su­mers owing to its high nut­ri­ti­ve value and poten­ti­al health bene­fits. Howe­ver, rab­bit meat is com­mon­ly more pro­ne to lipid per­oxi­da­ti­on during sto­ra­ge, with nega­ti­ve effects on qua­li­ty traits of meat, due to its ele­va­ted level of unsa­tu­ra­ti­on of fat­ty acids. Morin­ga olei­fe­ra lea­ves have gai­ned gre­at inte­rest owing to their high nut­ri­tio­nal value and low anti-nut­ri­tio­nal fac­tors. Morin­ga olei­fe­ra lea­ves could pos­si­b­ly avo­id oxi­da­ti­on dama­ge and exhi­bit anti­oxi­dant activi­ties that can con­quer free radi­cals and reac­tive oxy­gen spe­ci­es syn­the­sis. The­re­fo­re, the objec­tive of the cur­rent stu­dy was to eva­lua­te the effects of fee­ding Morin­ga olei­fe­ra lea­ves on per­for­mance, car­cass cha­rac­te­ris­tics, anti­oxi­dant capa­ci­ty, blood bio­che­mi­cal con­sti­tu­ents, meat qua­li­ty, and fat­ty acids pro­fi­le of gro­wing rab­bits. Morin­ga olei­fe­ra lea­ves sup­ple­men­ta­ti­on impro­ved weight gain, feed con­ver­si­on ratio, anti­oxi­dant sta­tus, and meat qua­li­ty cha­rac­te­ris­tics. Die­ta­ry Morin­ga olei­fe­ra lea­ves sup­ple­men­ta­ti­on enhan­ced PUFA con­tents, n-3 fat­ty acid, cru­de pro­te­in, and color of meat, but lowe­r­ed the rela­ti­ve con­tent of ether extract of the meat. Our fin­dings sug­gested that Morin­ga olei­fe­ra could be used at a level of 1.5 g/kg of the gro­wing rab­bits’ diets with bene­fi­ci­al impacts on per­for­mance and the nut­ri­tio­nal value of the meat.

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Effect of fee­ding Morin­ga tree pro­ducts on ewe milk com­po­si­ti­on and on the resul­tant yoghurt pro­per­ties

SM El-Sha­my, HH Sala­ma, AA Aboa­mer, MM Shaa­ban… — Egyp­ti­an Jour­nal of Food …, 2021

Morin­ga olei­fer tree pro­ducts are riches in various bioac­tive ingre­dients that have a good role in dai­ry pro­ducts. This work aimed to stu­dy the effect of adding dif­fe­rent Morin­ga tree pro­ducts (oil, lea­ve, and cake) in ewe’s rati­ons on milk com­po­si­ti­on as well as che­mi­cal, sen­so­ry and micro­bio­lo­gi­cal pro­per­ties of the resul­tant yoghurt. Thir­ty-five lac­ta­ting Bar­ki ewes were ran­dom­ly assi­gned into five groups. Each group was feed diet con­tai­ning dif­fe­rent rati­os and type of Morin­ga pro­ducts. The first group was con­trol © The other four groups were clas­sed as fol­low: Group (1): feed 2.5% Morin­ga seed cake: (MC1); Group (2): feed 5% Morin­ga seed cake: (MC2). Group (3): feed 1% Kg /DM Morin­ga oil (MO) Group (4): feed 15% of total DM Morin­ga lea­ves (ML). The che­mi­cal com­po­si­ti­ons of milk as well as the micro­bio­lo­gi­cal pro­per­ties of the resul­ting yoghurt were stu­di­ed fresh and during sto­ra­ge time. Results revea­led that milk com­po­si­ti­on signi­fi­cant­ly (P<0.05) increa­sed with diet fed on MC1 as com­pa­red to con­trol. The obser­ved pH dif­fe­ren­ces bet­ween dif­fe­rent yoghurts tre­at­ments are attri­bu­t­ed to dif­fe­ren­ces in che­mi­cal com­po­si­ti­on and high total solids of milk bet­ween groups. The dia­ce­tyl and ace­tal­de­hy­de con­tents of yoghurt sam­ples were hig­her in tre­at­ment than the con­trol. The count of S. ther­mo­phi­lus and L. bul­ga­ri­cus in all trea­ted yoghurt sam­ples was hig­her than in con­trol, while no signi­fi­cant dif­fe­rence obser­ved in the counts of S. ther­mo­phi­lus and L. bul­ga­ri­cus, eit­her in the con­trol or bet­ween yoghurt tre­at­ments. The yoghurt pro­du­ced from the dai­ry ewes’ fee­ding on Morin­ga olei­fe­ra pro­duct had good che­mi­cal and micro­bio­lo­gi­cal pro­per­ties. So, using it was con­clu­ded that fee­ding Morin­ga olei­fe­ra pro­ducts is effec­tive in the fee­ding of dai­ry ewes’ and other rumi­nant ani­mals.

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Effect of com­ple­te feed con­tai­ning Morin­ga olei­fe­ra and Sorghum suda­nen­se on milk yield of lac­ta­ting Mala­ba­ri goats.

P Priya, KS Ajith, K Ally, K Shy­a­ma… — Jour­nal of Vete­ri­na­ry and …, 2020

A stu­dy was con­duc­ted to com­pa­re the lac­ta­ti­on per­for­mance of Mala­ba­ri goats fed on two dif­fe­rent com­ple­te feeds con­tai­ning Morin­ga (T2) and fod­der sorghum (T3) with tho­se fed on con­ven­tio­nal rati­on (T1). The ani­mals in group T1 were fed on con­ven­tio­nal rati­on con­sis­ting of com­po­un­ded feed mix­tu­re (CFM) having 17.89 per cent cru­de pro­te­in (CP) and 68.90 per cent total diges­ti­ble nut­ri­ent (TDN) along with green grass. Com­ple­te feed con­tai­ning morin­ga lea­ves fed to goats in T2 group had 15.85 per cent CP and 66.85 per cent TDN while T3 group was fed on com­ple­te feed con­tai­ning sorghum having 15.90 per cent CP and 65.86 per cent TDN, respec­tively. The roughage:concentrate ratio was main­tai­ned at 30:70. The average dai­ly dry mat­ter inta­ke of goats in the three groups, T1, T2 and T3 were 1.46, 1.67 and 1.58 kg, respec­tively. The average dai­ly milk yield of goats in groups T1, T2 and T3 were found to be simi­lar to each other i.e., 0.81, 0.96 and 0.83 lit­re respec­tively (P>0.05). Hence it was con­clu­ded that the fee­ding of com­ple­te feed did affect neit­her the dry mat­ter inta­ke nor the milk yield of lac­ta­ting Mala­ba­ri goats.

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Tier­fut­ter / Full Text

month: 07  / year: 2020

Ani­mals (Basel). 2020 Jun 29;10(7):E1117.  doi: 10.3390/ani10071117.

Effect of Fee­ding Lac­ta­ting Ewes with Morin­ga olei­fe­ra Leaf Extract on Milk Yield, Milk Com­po­si­ti­on and Pre­wea­ning Per­for­mance of Ewe/Lamb Pair.Animals (Basel). 2020 Jun 29;10(7):E1117. doi: 10.3390/ani10071117.

The use of plant extracts as sup­ple­men­tal addi­ti­ves in rumi­nant diets shows bene­fi­ci­al effects. This stu­dy eva­lua­ted the effects of dif­fe­rent doses of Morin­ga olei­fe­ra leaf extract (MOE) on milk pro­duc­tion and milk com­po­si­ti­on in ewes and on pre­wea­ning per­for­mance of their lambs. At dif­fe­rent doses, MOE sup­ple­men­ta­ti­on did not affect over­all pro­duc­tive traits in ewes and lambs and did not have nega­ti­ve effects on milk pro­duc­tion and milk qua­li­ty.

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The objec­tive this stu­dy was to eva­lua­te the effect of dif­fe­rent doses of Morin­ga olei­fe­ra leaf extract (MOE) on milk pro­duc­tion and milk com­po­si­ti­on in ewes and on pre­wea­ning per­for­mance of their lambs. Twen­ty-four lac­ta­ting ewes were hou­sed indi­vi­dual­ly with their lambs and assi­gned to four groups in a com­ple­te­ly ran­do­mi­zed design. The tre­at­ments inclu­ded a basal diet without MOE (MOE0) or a basal diet sup­ple­men­ted with eit­her 20 mL MOE per ewe per day (MOE20), 40 mL MOE per ewe per day (MOE40) or 60 mL MOE per ewe per day (MOE60). Over 45 days, milk pro­duc­tion was recor­ded wee­kly and indi­vi­du­al milk sam­ples were collec­ted for che­mi­cal ana­ly­sis. Milk yield, fat-cor­rec­ted milk and dai­ly yiel­ds were simi­lar among the four tre­at­ments. The sup­ply of MOE did not affect ewe wea­ning effi­ci­en­cy and average dai­ly gain or lit­ter wea­ning weight of the lambs. Over­all, the results from this stu­dy show­ed that die­ta­ry sup­ple­men­ta­ti­on of hydro­al­co­ho­lic extracts of Morin­ga olei­fe­ra lea­ves at doses of 20, 40 or 60 mL/ewes/d in lac­ta­ting ewes does not have nega­ti­ve effects on milk yield, milk com­po­si­ti­on or lamb per­for­mance.

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Effect of die­ta­ry Morin­ga stem meal level on growth per­for­mance, slaugh­ter per­for­mance and serum bio­che­mi­cal para­me­ters in geese.

J Anim Phy­si­ol Anim Nutr (Berl). 2020 Jan;104(1):126–135. doi: 10.1111/jpn.13209. Epub 2019 Sep 18.

Morin­ga stem meal (MSM) with a high level of cru­de fib­re (CF) might be deve­lo­ped and uti­li­zed in her­bi­vo­r­ous geese as an uncon­ven­tio­nal feed­s­tuff. The aim of this stu­dy was to inves­ti­ga­te the effect of the MSM level in the diet on the growth per­for­mance, slaugh­ter per­for­mance, bre­ast meat qua­li­ty and serum bio­che­mi­cal para­me­ters in geese from 22 to 70 days of age. A one-fac­tor com­ple­te­ly ran­do­mi­zed design was adop­ted in our stu­dy. A total of one thousand eight 21-day-old geese were ran­dom­ly divi­ded into six groups, with six repli­ca­tes per group and 28 birds per repli­ca­te. The geese were fed diets con­tai­ning MSM levels of 0, 20, 40, 60, 80 or 100 g/kg during day 22–70. The die­ta­ry MSM level had no effect (p > .05) on the final body weight (BW), average dai­ly gain (ADG) or average dai­ly feed inta­ke (ADFI). The feed/gain ratio (F/G) increa­sed line­ar­ly (p < .001) as the die­ta­ry MSM level increa­sed. No dif­fe­ren­ces (p > .05) were obser­ved in the slaugh­ter per­for­mance, meat qua­li­ty and the rela­ti­ve organ weight (except for thy­mus) of the geese (p > .05). The rela­ti­ve weight of the thy­mus in the geese fed diets with sup­ple­men­ta­ti­on of MSM was hig­her than that in the non-sup­ple­men­ted MSM con­trol group (p < .05). In addi­ti­on, 100 g MSM/kg of diet decrea­sed the serum glu­co­se (GLU) level (p < .05) and increa­sed the ala­ni­ne tran­sa­mi­na­se (ALT) enzy­me activi­ty (p = .03). Die­ta­ry MSM levels of no more than 60 g/kg had no effects on the growth per­for­mance and slaugh­ter per­for­mance, whe­re­as diets with 100 g MSM/kg increa­sed the F/G and serum ALT enzy­me activi­ty, as well as decrea­sing the serum GLU level. The­re­fo­re, MSM pro­vi­ded at a rea­son­ab­le level could be deve­lo­ped as an uncon­ven­tio­nal feed­s­tuff for geese at the finis­her peri­od.

month: 12     year: 2018

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Tier­fut­ter / Full Text

J Eth­no­phar­ma­col. 2018 Dec 26;233:80–86. doi: 10.1016/j.jep.2018.12.036. [Epub ahead of print]

Hor­mo­nal chan­ges, semen qua­li­ty and vari­an­ce in repro­duc­tive activi­ty out­co­mes of post puber­tal rab­bits fed Morin­ga olei­fe­ra Lam. leaf powder.

J Eth­no­phar­ma­col. 2018, 26. Dezem­ber; 233: 80–86. doi: 10.1016 / j.jep.2018.12.036. [Epub vor Druck]

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Eth­no­phar­ma­co­lo­gi­cal rele­van­ce: Morin­ga olei­fe­ra Lam. (Moring­aceae) is an important plant based stap­le food, known for its nut­ri­tio­nal and medi­c­inal value and is usual­ly pre­scri­bed by her­bal prac­titio­ners in Nige­ria and in other tro­pi­cal coun­tries for the tre­at­ment of male infer­ti­li­ty pro­blems and repro­duc­tive disea­ses in fema­les. Alt­hough the aphro­di­siac pro­per­ties and fer­ti­li­ty enhan­ce­ment poten­ti­al in males have been repor­ted, the under­ly­ing mecha­nisms for the activi­ty remain unclear. In this stu­dy, we inves­ti­ga­ted the influ­ence of sup­ple­men­ting the diet with M. olei­fe­ra Lam. leaf powder on repro­duc­tive hor­mo­nes and semen qua­li­ty of New Zea­land White (NZW) rab­bits.

Mate­ri­als and methods: Thir­ty-two (32) NZW rab­bits of 50:50 ratio bucks to does, were ran­dom­ly dis­tri­bu­t­ed to four tre­at­ment groups (n = 4 bucks, n = 4 does per group). Gra­ded levels (0, 5, 10 and 15 g/kg) of M. olei­fe­ra Lam. leaf powder was incorpo­ra­ted into rab­bit gro­wers pel­let. The does and bucks were hou­sed sepa­r­a­te­ly in hut­ches and shel­te­red under the same envi­ron­men­tal con­di­ti­ons with free access to their respec­tive tre­at­ment diets for a peri­od of 12 weeks.

Results: In fema­le rab­bits, tre­at­ment revea­led signi­fi­cant (P < 0.05) dose-depen­dent reduc­tion in the con­cen­tra­ti­on of serum FSH, LH and oestro­gen. While in con­trast the hig­hest dose of leaf powder signi­fi­cant­ly (P < 0.05) increa­sed pro­ges­te­ro­ne and pro­lac­tin con­cen­tra­ti­ons remai­ned unaf­fec­ted. On the other hand, the con­cen­tra­ti­on of FSH and LH in bucks was signi­fi­cant­ly (P < 0.05) increa­sed in tre­at­ment groups com­pa­red to the con­trol group. Serum tes­to­ste­ro­ne con­cen­tra­ti­ons were signi­fi­cant­ly lower in the 5 and 10 g/kg tre­at­ment groups. Semen volu­me, sperm count and moti­li­ty were signi­fi­cant­ly impro­ved in a dose depen­dent man­ner with increa­sing amounts of M. olei­fe­ra Lam. leaf powder in the diet.

Con­clu­si­ons: We con­clu­de that M. olei­fe­ra Lam. leaf powder sup­ple­men­ta­ti­on to the diet was more bene­fi­ci­al to male rab­bit fer­ti­li­ty than the fema­le, whe­re it ten­ded to have a nega­ti­ve impact through the hypo­tha­l­a­mic-pitui­ta­ry-gona­dal axis. Howe­ver, with the vary­ing impact of M. olei­fe­ra Lam. leaf powder on the hypo­tha­l­a­mic-pitui­ta­ry-gona­dal axis of male and fema­le ani­mals, fur­t­her inves­ti­ga­ti­on is necessa­ry to deter­mi­ne the mecha­nism through which it ope­ra­tes.

Key­wor­ds: Fer­ti­li­ty hor­mo­nes; Morin­ga olei­fe­ra Lam. leaf; Rab­bit; Semen qua­li­ty.

 

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month: 10     year: 2016

Trop Anim Health Prod. 2016 Oct;48(7):1427–33. doi: 10.1007/s11250-016‑1111-9. Epub 2016 Jul 26.

Effect of par­ti­al repla­ce­ment of alfal­fa hay with Morin­ga spe­ci­es lea­ves on milk yield and com­po­si­ti­on of Naj­di ewes.

Trop Anim Health Prod. 2016 Okt; 48 (7): 1427–33. doi: 10.1007 / s11250-016‑1111-9. Epub 2016 26. Juli.

The pre­sent stu­dy was car­ri­ed out to inves­ti­ga­te chan­ges in milk yield and com­po­si­ti­on of Naj­di ewes fed 25 % Morin­ga olei­fe­ra (MOD) or Morin­ga pere­gri­na (MPD) leaf diets as a sup­ple­ment to alfal­fa hay diet (AHD). Thir­ty ewes (average 55 kg, 2 years old) were ran­dom­ly sor­ted into three expe­ri­men­tal groups with 10 ani­mals each and were fed for a 6-week peri­od with the­se diets (AHD, MOD, or MPD). Diets dry mat­ter, cru­de pro­te­in, and cru­de fiber were com­pa­ra­ble, while fat, nitro­gen-free extract (NFE), neu­tral deter­gent fiber (NDF), acid deter­gent fiber (ADF), meta­bo­liz­ab­le ener­gy (ME), total phe­n­o­lic, and anti­oxi­dant activi­ty varied (p ≤ 0.05) bet­ween the diets. Fee­ding ewes with MOD increa­sed (p ≤ 0.05) the milk yield com­pa­red to tho­se fed AHD while milk com­po­si­ti­on was simi­lar (p ≤ 0.05) bet­ween tre­at­ments. The con­cen­tra­ti­on of malon­di­al­de­hy­de (MDA) in the ewes‘ milk and serum was lower (p ≤ 0.05) for MOD, while the total anti­oxi­dant capa­ci­ty, cata­la­se activi­ty, and vit­amin C con­tents were increa­sed (p ≤ 0.05). The serum cho­le­ste­rol and glu­co­se of the ewes were lower (p ≤ 0.05) for tho­se fed MOD. Moringa­diets increa­sed (p ≤ 0.05) average dai­ly weight gain of lambs com­pa­red to tho­se fed alfal­fa diets. The results obtai­ned show­ed that the inclu­si­on of Morin­ga, espe­ci­al­ly M. olei­fe­ra, in the diet of Naj­di ewes can impro­ve milk yield and qua­li­ty.

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Methyl-coen­zy­me M Reduc­ta­se (MCR) Recep­tor as Poten­ti­al Drug Tar­get for Inhi­bi­ting Metha­no­ge­ne­sis in Hor­ses Using Morin­ga olei­fe­ra L.: An in Sili­co Docking Stu­dy

Abs­tract

Metha­ne (CH4) emis­si­on from non­rumi­nant live­stock, par­ti­cu­lar­ly equi­nes, is a colos­sal bur­den for vete­ri­na­ri­ans world­wi­de. In view of this, the pre­sent con­text was inves­ti­ga­ted to pre­dict the anti­me­tha­no­ge­nic attri­bu­tes of Morin­ga olei­fe­ra L. asso­cia­ted phy­to­com­pon­ents by tar­ge­ting methyl-coen­zy­me M reduc­ta­se (MCR) recep­tor in hor­ses using in sili­co tools. Initi­al­ly, the phar­ma­co­ki­ne­tics and ADME (absorp­ti­on, dis­tri­bu­ti­on, meta­bo­lism, and excre­ti­on) pro­per­ties of 26 phy­to­com­pon­ents were ana­ly­zed using Lipinski’s rule of five and Swiss ADME tool, respec­tively. Among all the tested phy­to­com­pon­ents, 3,5-bis(1,1-dimethylethyl)-phenol, Kaemp­fe­rol, Morin­gy­ne, Nia­zi­mi­sin, and Tetra­de­ca­noic acid show­ed drug-like­ness traits with no vio­la­ti­on. The mole­cu­lar docking ana­ly­sis of selec­ted phy­to­com­pon­ents against MCR recep­tor was car­ri­ed out using Hex 8.0.0 docking soft­ware. Results esti­ma­ted the hig­hest bin­ding ener­gy of Tetra­de­ca­noic acid against MCR recep­tor with maxi­mum docking E-value of −142.98 KJ/mol, fol­lo­wed by Nia­zi­mi­sin (−133.98 KJ/mol), Kaemp­fe­rol (−110.36 KJ/mol), 3,5-bis(1,1-dimethylethyl)-phenol (−93.72 KJ/mol), and Morin­gy­ne (−92.62 KJ/mol). In con­clu­si­on, Tetra­de­ca­noic acid can be uti­li­zed as a pro­noun­ced anti­me­tha­no­ge­nic agent in order to deve­lop effi­cacious CH4 miti­ga­ting drugs by inhi­bi­ting the metha­no­ge­ne­sis mecha­nism. Most import­ant­ly, this in sili­co out­co­mes can cer­tain­ly redu­ce the cost of in vivo stu­dies stra­te­gy toward the deve­lop­ment of anti­me­tha­no­ge­nic drugs for hor­ses in the future.

 

All­ge­mein / meist Zusam­men­fas­sun­gen (Reviews)

All­ge­mein (full text)

A Review of the Phy­to­che­mi­cal and Phar­ma­co­lo­gi­cal Cha­rac­te­ris­tics of Morin­ga olei­fe­ra.

J Pharm Bio­al­lied Sci. 2018 Oct-Dec;10(4):181–191. doi: 10.4103/JPBS.JPBS_126_18.

Morin­ga olei­fe­ra is a valued medi­c­inal plant in tra­di­tio­nal folk medi­ci­ne. Many phar­ma­co­lo­gi­cal stu­dies have shown the abi­li­ty of this plant to exhi­bit anal­ge­sic, anti-inflamma­to­ry, anti­py­retic, anti­can­cer, anti­oxi­dant, nootro­pic, hepa­to­pro­tec­tive, gastro­pro­tec­tive, anti-ulcer, car­dio­vascu­lar, anti-obe­si­ty, anti­epi­lep­tic, anti­asth­ma­tic, anti­dia­betic, anti-uro­li­th­ia­tic, diuretic, local anesthetic, anti-all­er­gic, ant­hel­min­tic, wound healing, anti­mi­cro­bi­al, immu­no­mo­du­la­to­ry, and anti­di­ar­r­he­al pro­per­ties. This review is a com­pre­hen­si­ve sum­ma­ry of the phy­to­che­mi­cal and phar­ma­co­lo­gi­cal activi­ties as well as the tra­di­tio­nal and the­ra­peutic uses of this plant. M. olei­fe­ra has wide tra­di­tio­nal and phar­ma­co­lo­gi­cal uses in various patho­phy­sio­lo­gi­cal con­di­ti­ons. We will review the various pro­per­ties of M. olei­fe­ra (drum­stick tree) and focus on its various medi­c­inal pro­per­ties. We think that it is an attrac­tive sub­ject for fur­t­her expe­ri­men­tal and cli­ni­cal inves­ti­ga­ti­ons.

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All­ge­mein (full text)

Phy­to­che­mi­stry and Phar­ma­co­lo­gy of Morin­ga olei­fe­ra Lam.

J Phar­ma­co­punc­tu­re. 2017 Sep;20(3):194–200. doi: 10.3831/KPI.2017.20.022. Epub 2017 Sep 30.

Morin­ga olei­fe­ra Lam. or mun­ga is one of the most important plant wide­ly cul­ti­va­ted in India. It belongs to fami­ly Moring­aceae. This plant is wide­ly used as nut­ri­tio­nal herb and con­ta­ins valu­able phar­ma­co­lo­gi­cal action like anti-asth­ma­tic, anti-dia­betic, hepa­to­pro­tec­tive, anti-inflamma­to­ry, anti- fer­ti­li­ty, anti-can­cer, anti-micro­bi­al, anti-oxidant, car­dio­vascu­lar, anti-ulcer, CNS activi­ty, anti-all­er­gic, wound healing, anal­ge­sic, and anti­py­retic activi­ty, Morin­ga olei­fe­ra Lam. The plant is also known as Hor­se – radish tree, Drum­stick tree. Every part of this plant con­ta­ins a valu­able medi­c­inal fea­ture. It con­tain rich source of the vit­amin A, vit­amin C and milk pro­te­in. Dif­fe­rent types of active phy­to­con­sti­tu­ents like alka­lo­ids, pro­te­in, qui­ni­ne, saponins, fla­vo­no­ids, tan­nin, ste­ro­ids, gly­co­si­des, fixed oil and fats are pre­sent. This plant is also found in the tro­pi­cal regi­ons. Some other con­sti­tu­ents are nia­zin­in A, nia­zin­in B and nia­zi­micin A, nia­zi­mi­nin B. The pre­sent review dis­cus­ses the phy­to­che­mi­cal com­po­si­ti­on, medi­c­inal uses & phar­ma­co­lo­gi­cal activi­ty of this plant.

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All­ge­mein (full text)

Nut­raceuti­cal or Phar­ma­co­lo­gi­cal Poten­ti­al of Morin­ga olei­fe­ra Lam.

Nut­ri­ents. 2018 Mar 12;10(3). pii: E343. doi: 10.3390/nu10030343.

Morin­ga olei­fe­ra Lam. (M. olei­fe­ra), which belongs to the Moring­aceae fami­ly, is a peren­ni­al deci­duous tro­pi­cal tree, and nati­ve to the south of the Hima­la­y­an Moun­ta­ins in nort­hern India. M. olei­fe­ra is rich in pro­te­ins, vit­amin A, mine­rals, essen­ti­al ami­no acids, anti­oxi­d­ants, and fla­vo­no­ids, as well as isot­hio­cya­na­tes. The extracts from M. olei­fe­ra exhi­bit mul­ti­ple nut­raceuti­cal or phar­ma­co­lo­gi­cal func­tions inclu­ding anti-inflamma­to­ry, anti­oxi­dant, anti-can­cer, hepa­to­pro­tec­tive, neu­ro­pro­tec­tive, hypo­gly­ce­mic, and blood lipid-redu­cing func­tions. The bene­fi­ci­al func­tions of M. olei­fe­ra are stron­gly asso­cia­ted with its phy­to­che­mi­cals such as fla­vo­no­ids or isot­hio­cya­na­tes with bioac­tivi­ty. In this review, we sum­ma­ri­ze the rese­arch pro­gress rela­ted to the bioac­tivi­ty and phar­ma­co­lo­gi­cal mecha­nisms of M. olei­fe­ra in the pre­ven­ti­on and tre­at­ment of a series of chro­nic disea­ses-inclu­ding inflamma­to­ry disea­ses, neu­ro-dys­func­tio­nal disea­ses, dia­be­tes, and can­cers-which will pro­vi­de a refe­rence for its poten­ti­al app­li­ca­ti­on in the pre­ven­ti­on and tre­at­ment of chro­nic disea­ses or health pro­mo­ti­on.

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All­ge­mein (full text)

Morin­ga Genus: A Review of Phy­to­che­mi­stry and Phar­ma­co­lo­gy

Front Phar­ma­col. 2018; 9: 108. Published online 2018 Feb 16.

Morin­ga is a genus of medi­c­inal plants that has been used tra­di­tio­nal­ly to cure wounds and various disea­ses such as colds and dia­be­tes. In addi­ti­on, the genus is also con­su­med as a source of nut­ri­ents and wide­ly used for puri­fy­ing water. The genus con­sists of 13 spe­ci­es that have been wide­ly cul­ti­va­ted throug­hout Asia and Afri­ca for their mul­ti­ple uses. The pur­po­se of this review is to pro­vi­de updated and cate­go­ri­zed infor­ma­ti­on on the tra­di­tio­nal uses, phy­to­che­mi­stry, bio­lo­gi­cal activi­ties, and toxi­co­lo­gi­cal rese­arch of Morin­ga spe­ci­es in order to explo­re their the­ra­peutic poten­ti­al and eva­lua­te future rese­arch oppor­tu­nities. The lite­ra­tu­re review­ed for this paper was obtai­ned from PubMed, Sci­en­ce­Di­rect, and Goog­le Scho­l­ar jour­nal papers published from 1983 to March 2017. Morin­ga spe­ci­es are well-known for their anti­oxi­dant, anti-inflamma­to­ry, anti­can­cer, and anti­hy­per­gly­ce­mic activi­ties. Most of their bio­lo­gi­cal activi­ty is cau­sed by their high con­tent of fla­vo­no­ids, glu­co­si­des, and glu­co­si­no­la­tes. By docu­men­ting the tra­di­tio­nal uses and bio­lo­gi­cal activi­ties of Morin­ga spe­ci­es, we hope to sup­port new rese­arch on the­se plants, espe­ci­al­ly on tho­se spe­ci­es who­se bio­lo­gi­cal pro­per­ties have not been stu­di­ed to date.

Morin­ga is a genus of medi­c­inal plants that has been used tra­di­tio­nal­ly to cure wounds and various disea­ses such as colds and dia­be­tes. In addi­ti­on, the genus is also con­su­med as a source of nut­ri­ents and wide­ly used for puri­fy­ing water. The genus con­sists of 13 spe­ci­es that have been wide­ly cul­ti­va­ted throug­hout Asia and Afri­ca for their mul­ti­ple uses. The pur­po­se of this review is to pro­vi­de updated and cate­go­ri­zed infor­ma­ti­on on the tra­di­tio­nal uses, phy­to­che­mi­stry, bio­lo­gi­cal activi­ties, and toxi­co­lo­gi­cal rese­arch of Morin­ga spe­ci­es in order to explo­re their the­ra­peutic poten­ti­al and eva­lua­te future rese­arch oppor­tu­nities. The lite­ra­tu­re review­ed for this paper was obtai­ned from PubMed, Sci­en­ce­Di­rect, and Goog­le Scho­l­ar jour­nal papers published from 1983 to March 2017. Morin­ga spe­ci­es are well-known for their anti­oxi­dant, anti-inflamma­to­ry, anti­can­cer, and anti­hy­per­gly­ce­mic activi­ties. Most of their bio­lo­gi­cal activi­ty is cau­sed by their high con­tent of fla­vo­no­ids, glu­co­si­des, and glu­co­si­no­la­tes. By docu­men­ting the tra­di­tio­nal uses and bio­lo­gi­cal activi­ties of Morin­ga spe­ci­es, we hope to sup­port new rese­arch on the­se plants, espe­ci­al­ly on tho­se spe­ci­es who­se bio­lo­gi­cal pro­per­ties have not been stu­di­ed to date

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All­ge­mein (full text)

MINI REVIEW ARTICLE

Front. Phar­ma­col., 17 Decem­ber 2020 | https://doi.org/10.3389/fphar.2020.566783

Morin­ga olei­fe­ra Lam and its The­ra­peutic Effects in Immu­ne Dis­or­ders

Morin­ga olei­fe­ra Lam., a plant nati­ve to tro­pi­cal forests of India, is cha­rac­te­ri­zed by its ver­sa­ti­le app­li­ca­ti­on as a food addi­ti­ve and sup­ple­ment the­ra­py. Accu­mu­la­ting evi­dence shows that Morin­ga plays a cri­ti­cal role in immu­ne-rela­ted disea­ses. In this review, we cover the histo­ry, con­sti­tu­ents, edi­bi­li­ty, and gene­ral medi­c­inal value of Morin­ga. The effects of Morin­ga in trea­ting immu­ne dis­or­ders are dis­cus­sed in detail. Morin­ga can not only eli­mi­na­te patho­gens, inclu­ding bac­te­ria, fun­gi, viru­ses, and para­si­tes, but also inhi­bit chro­nic inflamma­ti­on, such as asth­ma, ulce­ra­ti­ve coli­tis, and meta­bo­lic disea­ses. Addi­tio­nal­ly, Morin­ga can atte­nua­te phy­si­cal and che­mi­cal irri­ta­ti­on-indu­ced immu­ne dis­or­ders, such as metal into­xi­ca­ti­on, drug side effects, or even the adver­se effect of food addi­ti­ves. Auto­im­mu­ne disea­ses, like rheu­ma­to­id arthri­tis, ato­pic der­ma­ti­tis, and mul­ti­ple scle­ro­sis, can also be inhi­bi­ted by Morin­ga. Collec­tively, Morin­ga, with its mul­ti­ple immu­ne regu­la­to­ry bioac­tivi­ties and few side effects, has a mar­ked poten­ti­al to tre­at immu­ne dis­or­ders.

 

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All­ge­mein (full text)

Bioac­tive Com­pon­ents in Morin­ga Olei­fe­ra Lea­ves Pro­tect against Chro­nic Disea­se.

Anti­oxi­d­ants (Basel). 2017 Nov 16;6(4). pii: E91. doi: 10.3390/antiox6040091.

Morin­ga Olei­fe­ra (MO), a plant from the fami­ly Moring­acea is a major crop in Asia and Afri­ca. MO has been stu­di­ed for its health pro­per­ties, attri­bu­t­ed to the nume­rous bioac­tive com­pon­ents, inclu­ding vit­amins, phe­n­o­lic acids, fla­vo­no­ids, isot­hio­cya­na­tes, tan­nins and saponins, which are pre­sent in signi­fi­cant amounts in various com­pon­ents of the plant. Morin­ga Olei­fe­ra lea­ves are the most wide­ly stu­di­ed and they have shown to be bene­fi­ci­al in several chro­nic con­di­ti­ons, inclu­ding hyper­cho­le­ste­ro­le­mia, high blood pres­su­re, dia­be­tes, insu­lin resis­tan­ce, non-alco­ho­lic liver disea­se, can­cer and over­all inflamma­ti­on. In this review, we pre­sent infor­ma­ti­on on the bene­fi­ci­al results that have been repor­ted on the pre­ven­ti­on and alle­via­ti­on of the­se chro­nic con­di­ti­ons in various ani­mal models and in cell stu­dies. The exis­ting limi­ted infor­ma­ti­on on human stu­dies and Morin­ga Olei­fera­lea­ves is also pre­sen­ted. Over­all, it has been well docu­men­ted that Morin­ga Olei­fe­ra lea­ves are a good stra­te­gic for various con­di­ti­ons asso­cia­ted with heart disea­se, dia­be­tes, can­cer and fat­ty liver.

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All­ge­mein (full text)

App­li­ca­ti­on of Morin­ga (Morin­ga olei­fe­ra) as Natu­ral Feed Sup­ple­ment in Poul­try Diets.

Ani­mals (Basel). 2019 Jul 9;9(7):431. doi: 10.3390/ani9070431.

App­li­ca­ti­on of natu­ral herbs with a view to enhan­cing pro­duc­tion per­for­mance and health sta­tus has crea­ted an important demand in poul­try pro­duc­tion. With the increa­sing con­cerns on this issue, grea­ter atten­ti­on paid to alter­na­ti­ves to anti­bio­tics for orga­nic meat and egg pro­duc­tion has led to a gre­at demand. This stu­dy was con­duc­ted with view to asses­sing the pos­si­ble role of M. olei­fe­ra as a natu­ral feed sup­ple­ment in poul­try rati­on. Various sci­en­ti­fic fin­dings and published rese­arch arti­cles were con­s­i­de­red con­cer­ning issu­es inclu­ding the stu­dy back­ground, objec­tives, major fin­dings, and con­clu­si­ons of the review. M olei­fe­ra is known as a mira­cle tree becau­se of its wealt­hy resour­ce of various nut­ri­ents with high bio­lo­gi­cal values. M. olei­fe­ra has been used as a growth pro­mo­ter, immu­ne enhan­cer, anti­oxi­dant, and has a hypo-cho­le­ste­rol effect on chi­ckens. It has both nut­ri­tio­nal and the­ra­peutic values. Howe­ver, the­re is still much con­fu­si­on in past published arti­cles invol­ving the major roles of M. olei­fe­ra in pro­duc­tion per­for­mance and health sta­tus of chi­ckens. Taking this into account, the pre­sent stu­dy high­lights an out­line of the expe­ri­men­tal uses of M. olei­fe­ra on growth per­for­mance, egg pro­duc­tion per­for­mance, egg qua­li­ty, and health sta­tus in broi­lers and lay­ing hens jus­ti­fied with the past fin­dings to the pre­sent. The know­ledge gaps from the past stu­dies are con­s­i­de­red, and the fea­si­bi­li­ty of M. olei­fe­ra in poul­try rati­on is sug­gested. The fin­dings have moti­va­ted fur­t­her stu­dy on M. olei­fe­ra to find out the most active ingre­dients and their opti­mal doses in both broi­ler and lay­ing hen rati­ons. Final­ly, the pre­sent stu­dy high­lights that sup­ple­men­ta­ti­on of M. olei­fe­ra may play a role in the immu­ni­ty, sound health, and pro­duc­tion per­for­mance in poul­try.

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All­ge­mein (full text)

Effect of Fora­ge Morin­ga olei­fe­ra L. (morin­ga) on Ani­mal Health and Nut­ri­ti­on and Its Bene­fi­ci­al App­li­ca­ti­ons in Soil, Plants and Water Puri­fi­ca­ti­on

Agri­cul­tu­re 2018, 8(9), 145; https://doi.org/10.3390/agriculture8090145

Morin­ga olei­fe­ra L. (morin­ga) is known as one of the most use­ful mul­tipur­po­se plants. It can be effec­tively uti­li­zed as a natu­ral bio­pesti­ci­de and inhi­bi­tor of several plant patho­gens. Thus, it can be inclu­ded in inte­gra­ted pest manage­ment stra­te­gies. Morin­ga and its pro­ducts have dif­fe­rent uses in many agri­cul­tu­ral sys­tems. The use of morin­ga as a crop enhan­cer is an eco-fri­end­ly way of impro­ving crop yiel­ds at the lowest pos­si­ble cost. This inex­pen­si­ve increa­se in pro­duc­tivi­ty can con­tri­bu­te to mee­ting some of the food needs in some parts of the world as the glo­bal popu­la­ti­on increa­ses and pover­ty rates rise. One of the most important cha­rac­te­ris­tics of morin­ga is that it has high bio­lo­gi­cal and nut­ri­tio­nal values and can be used as ani­mal feed, green fer­ti­li­zer, medi­ci­ne, bio­pesti­ci­de and in seed pro­duc­tion. Morin­ga has been cha­rac­te­ri­zed as a poten­ti­al­ly use­ful ani­mal feed owing to its high con­tent of pro­te­in, caro­te­no­ids, several mine­rals and vit­amins (such as iron and ascor­bic acid) and cer­tain phy­to­che­mi­cals (kaemp­feri­trin, iso­quer­ci­trin, rham­netin, kaemp­fe­rol and quer­ce­tin). This review aims to pro­vi­de more know­ledge about the natu­re, nut­ri­tio­nal value, phy­to­che­mi­cals and uses of Morin­ga olei­fe­ra as a pro­mi­sing mate­ri­al in the fiel­ds of soil and plant manage­ment, water tre­at­ment, as well as ani­mal and poul­try pro­duc­tion.

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All­ge­mein (full text)

Morin­ga olei­fe­ra Lam. A mira­cu­lous medi­c­inal plant: Review

Abs­tract: The pur­po­se of the review is to pro­vi­de gene­ral infor­ma­ti­on and rese­arch stu­dies of Morin­ga olei­fe­ra to rese­ar­chers to search the new phy­to-con­sti­tu­ent or mole­cu­les from the plant that may be valu­able for the­ra­peutic pur­po­se. M. olei­fe­ra is a popu­lar medi­c­inal and vege­ta­ble plant. It is com­mon­ly dis­tri­bu­t­ed in dif­fe­rent part of world. It has many the­ra­peutic effects. It is also well known for its nut­ri­tio­nal value. It con­ta­ins many mine­rals such as cal­ci­um, pot­as­si­um, magne­si­um, vit­amin A, and C, beta-caro­te­ne quer­ce­tin and kaemp­fe­rol. It pos­ses­ses several phar­ma­co­lo­gi­cal activi­ties such as anti­oxi­dant, anti-inflamma­to­ry, car­dio­pro­tec­tive, anti­bac­te­ri­al, anti­fun­gal and gastro­pro­tec­tive activi­ty. The pre­sent review pro­vi­des the infor­ma­ti­on regar­ding the phy­to­con­sti­tu­ents and phar­ma­co­lo­gi­cal poten­ti­al of the plant.

 

Dia­be­tes

Dia­be­tes (full text)

Poten­ti­al of Morin­ga olei­fe­ra to Impro­ve Glu­co­se Con­trol for the Pre­ven­ti­on of Dia­be­tes and Rela­ted Meta­bo­lic Alte­ra­ti­ons: A Sys­te­ma­tic Review of Ani­mal and Human Stu­dies.

Nut­ri­ents. 2020 Jul 10;12(7):E2050. doi: 10.3390/nu12072050.

Morin­ga olei­fe­ra (MO) is a mul­tipur­po­se plant con­su­med as food and known for its medi­c­inal uses, among others. Lea­ves, seeds and pods are the main parts used as food or food sup­ple­ments. Nut­ri­tio­nal­ly rich and with a high poly­phe­nol con­tent in the form of phe­n­o­lic acids, fla­vo­no­ids and glu­co­si­no­la­tes, MO has been shown to exert nume­rous in vitro activi­ties and in vivo effects, inclu­ding hypo­gly­ce­mic activi­ty. A sys­te­ma­tic search was car­ri­ed out in the PubMed data­ba­se and refe­rence lists on the effects of MO on glu­co­se meta­bo­lism. Thir­ty-three ani­mal stu­dies and eight human stu­dies were inclu­ded. Water and orga­nic sol­vent extracts of lea­ves and, second­ly, seeds, have been exten­si­ve­ly assay­ed in ani­mal models, sho­wing the hypo­gly­ce­mic effect, both under acu­te con­di­ti­ons and in long-term admi­nis­tra­ti­ons and also pre­ven­ti­on of other meta­bo­lic chan­ges and com­pli­ca­ti­ons asso­cia­ted to the hyper­gly­ce­mic sta­tus. In humans, cli­ni­cal tri­als are scar­ce, with varia­ble designs and tes­ting main­ly dry leaf powder alo­ne or mixed with other foods or MO aqueous pre­pa­ra­ti­ons. Alt­hough the repor­ted results are encou­ra­ging, espe­ci­al­ly tho­se from post­pran­di­al stu­dies, more human stu­dies are cer­tain­ly nee­ded with more strin­gent inclu­si­on cri­te­ria and a suf­fi­ci­ent num­ber of dia­betic or pre­dia­betic sub­jects. Moreo­ver, try­ing to quan­ti­fy the bioac­tive sub­s­tan­ces admi­nis­te­red with the expe­ri­men­tal mate­ri­al tested would faci­li­ta­te com­pa­ri­son bet­ween stu­dies.

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Dia­be­tes (abs­tract)

The effects of Morin­ga olei­fe­ra on blood glu­co­se levels: A sco­ping review of the lite­ra­tu­re

Fre­de­rick S Owens 3rd 1, Olu­wa­bun­mi Dada 2, John W Cyrus 3, Oreo­lu­wa O Ade­doy­in 4, Geor­ges Adun­lin 5

Abs­tract

Dia­be­tes is an increa­singly pro­ble­ma­tic health con­cern in the United Sta­tes. Morin­ga olei­fe­ra (M. olei­fe­ra) has been sug­gested as medi­ca­ti­on in the pre­ven­ti­on or tre­at­ment of dia­be­tes, but the­re is no con­vin­cing evi­dence of a cau­sal rela­ti­on bet­ween morin­ga and decrea­sed blood sugar levels in humans. The pur­po­se of this sco­ping review is to exami­ne the effects of Morin­ga olei­fe­ra on blood glu­co­se levels in rats and humans. A search of Sco­pus, Ovid Med­li­ne, Ovid Emba­se, IPA, and Web of Sci­ence and manu­al sear­ching of biblio­gra­phies were per­for­med for peer-review­ed English arti­cles published bet­ween May 1, 2008 and May 1, 2018. This review inclu­ded thir­ty stu­dies. Out of seven human stu­dies, five found that M. olei­fe­ra signi­fi­cant­ly redu­ced blood glu­co­se levels in dia­betic pati­ents. Out of twen­ty-three ani­mal stu­dies, twen­ty-one found that admi­nis­tra­ti­on of M. olei­fe­ra led to a sta­tis­ti­cal­ly signi­fi­cant decrea­se in ani­mal blood glu­co­se levels. In human stu­dies, morin­ga was most­ly admi­nis­te­red in a powde­red leaf form, while in ani­mal stu­dies it was fre­quent­ly admi­nis­te­red to as an aqueous or etha­nol-based extract. The review found sta­tis­ti­cal evi­dence that morin­ga decrea­sed blood glu­co­se; the evi­dence is not strong enough to recom­mend it as the default tre­at­ment for peop­le with dia­be­tes.

Key­wor­ds: Anti­dia­betic; Aqueous; Blood glu­co­se; Etha­nol; Morin­ga olei­fe­ra.

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Dia­be­tes (full text)

Effects of Morin­ga olei­fe­ra on Gly­cae­mia and Insu­lin Levels: A Review of Ani­mal and Human Stu­dies.

Nut­ri­ents. 2019 Dec 2;11(12):2907. doi: 10.3390/nu11122907.

Dia­be­tes and rela­ted neu­ro­lo­gi­cal com­pli­ca­ti­ons are serious world­wi­de public health pro­blems. The increa­sing num­ber of affec­ted indi­vi­du­als make it necessa­ry to imple­ment novel nut­ri­tio­nal and the­ra­peutic inter­ven­ti­ons. The tree Morin­ga olei­fe­ra (MO) has been used as a food source and for tra­di­tio­nal medi­ci­ne pur­po­ses due to pos­si­ble anti­hy­per­gly­ce­mic, anti­oxi­dant, anti-inflamma­to­ry, and lipid regu­la­ting pro­per­ties. The­se pro­per­ties may be exp­lai­ned by the pre­sence of nume­rous phy­to­che­mi­cals in the lea­ves, fruits, roots and, oil of the tree. The evi­dence for acu­te anti­hy­per­gly­ce­mic effects of MO extract on dia­betic ani­mal models seems to be robust, but more chro­nic and long-term stu­dies are nee­ded. In con­trast, the hypo­gly­ce­mic effects of MO on humans are not as clear. The scar­ce num­ber of human stu­dies, toge­ther with a diver­se ran­ge of metho­do­lo­gies and MO doses, may exp­lain this. In addi­ti­on, evi­dence regar­ding chan­ges in insu­lin levels due to MO inter­ven­ti­on is ambi­guous, both in ani­mal and human stu­dies. The­re­fo­re, more struc­tu­red stu­dies are nee­ded to cla­ri­fy if MO has an effect on insu­lin levels or activi­ty.

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Dia­be­tes (abs­tract)

Morin­ga olei­fe­ra and gly­ce­mic con­trol: A review of cur­rent evi­dence and pos­si­ble mecha­nisms.

Phy­to­ther Res. 2019 Nov;33(11):2841–2848. doi: 10.1002/ptr.6473. Epub 2019 Aug 19.

Main­tai­ning gly­ce­mic con­trol in dia­be­tes and pre­dia­be­tes is necessa­ry to pre­vent many health com­pli­ca­ti­ons and mor­ta­li­ty. Alt­hough dif­fe­rent hypo­gly­ce­mic drugs are used for this pur­po­se, the­re is still a gro­wing inte­rest in the use of medi­c­inal plants due to their low pri­ce, easy avai­la­bi­li­ty, and fewer or no side effects. Morin­ga (Morin­ga olei­fe­ra Lam.) is a medi­c­inal plant that has been tra­di­tio­nal­ly used in the manage­ment of dia­be­tes. This review aims to pre­sent the exis­ting lite­ra­tu­re published until Febru­ary 2019 on the role of morin­ga lea­ves in gly­ce­mia and their phy­sio­lo­gi­cal mecha­nisms. In the con­duc­ted stu­dies, morin­ga lea­ves have shown to redu­ce gly­ce­mia, without causing any adver­se effects. The pro­po­sed mecha­nisms for redu­cing gly­ce­mia inclu­de inhi­bi­ti­on of α-amy­la­se and α-glu­co­si­da­se activi­ties, increa­sed glu­co­se upt­ake in the mus­cles and liver, inhi­bi­ti­on of glu­co­se upt­ake from the intes­ti­ne, decrea­sed glu­co­neo­ge­ne­sis in the liver, and increa­sed insu­lin secre­ti­on and sen­si­ti­vi­ty. Howe­ver, the­se stu­dies are limi­ted in num­bers and most­ly con­duc­ted in ani­mals, in vitro and in vivo. The­re­fo­re, long-term human stu­dies are requi­red to deter­mi­ne the hypo­gly­ce­mic effect of morin­ga lea­ves, their phy­sio­lo­gi­cal mecha­nisms, active ingre­dients, and safe­ty. Over­all, this review pro­vi­des evi­dence that morin­ga lea­ves have the pos­si­bi­li­ty to be used as a gly­ce­mic con­trol agent in dia­be­tes and pre­dia­be­tes.

 

Unter­ernäh­rung

Unter­ernäh­rung (abs­tract)

Qua­li­ta­ti­ve Micro­bio­lo­gi­cal Risk Assess­ment of Morin­ga olei­fe­ra Leaf Powder To Be Used To Tre­at Under­nut­ri­ti­on in Infants and Child­ren in Cam­bo­dia and India: A Review.

J Food Prot. 2019 Feb 27:513–521. doi: 10.4315/0362–028X.JFP-18–252. [Epub ahead of print]

This qua­li­ta­ti­ve risk assess­ment (QRA) was con­duc­ted to esti­ma­te the micro­bio­lo­gi­cal risk asso­cia­ted with the con­sump­ti­on of Morin­ga olei­fe­ra leaf powder (MLP) by infants and child­ren ages 6 to 23 mon­ths to pre­vent or tre­at under­nut­ri­ti­on in Siem Reap, Cam­bo­dia, and Mad­hya Pra­desh, India. This QRA fol­lows the Codex Ali­men­ta­ri­us Com­mis­si­on princi­ples and gui­de­li­nes for risk assess­ment and takes into account all known micro­bi­al hazards that are asso­cia­ted with MLP. A com­pre­hen­si­ve lite­ra­tu­re search was car­ri­ed out for food­bor­ne patho­gens iso­la­ted from MLP and other dried foods of simi­lar con­sis­ten­cy, such as dried herbs and spi­ces and flour. From this lite­ra­tu­re search, the fol­lo­wing patho­gens were iden­ti­fied and con­s­i­de­red for this micro­bio­lo­gi­cal QRA: Bac­il­lus cere­us, Esche­ri­chia coli, Cam­py­lo­bac­ter spp., Clo­s­tri­di­um per­frin­gens, Cro­no­bac­ter spp., Lis­te­ria mono­cy­to­ge­nes, Sal­mo­nel­la spp., and Sta­phy­lo­coc­cus aure­us. Results sug­gest that when cere­al slur­ry (por­ridge) forti­fied with MLP is boi­led (a rol­ling boil for 5 min) pri­or to con­sump­ti­on, the food safe­ty risk to under­nou­ris­hed infants and child­ren of B. cere­us, C. per­frin­gens type A, Cro­no­bac­ter, ent­e­ro­he­mor­r­ha­gic E. coli, L. mono­cy­to­ge­nes, Sal­mo­nel­la spp., and S. aure­us is low to mode­ra­te, with only a mode­ra­te to serious risk posed by C. per­frin­gens type C. Howe­ver, when the forti­fied por­ridge is not boi­led befo­re con­sump­ti­on, the food safe­ty risk is increa­sed for all of the eva­lua­ted patho­gens. Over­all, the QRA sug­gests that MLP pres­ents a risk to under­nou­ris­hed infants and child­ren. Howe­ver, this risk can be miti­ga­ted when the powder is stored under the appro­pria­te con­di­ti­ons to ensu­re the­re is no ingress of mois­tu­re and then pro­ces­sed in a hygie­nic man­ner to redu­ce con­ta­mi­na­ti­on and/or cross-con­ta­mi­na­ti­on by fol­lo­wing hazard ana­ly­sis cri­ti­cal con­trol point or simi­lar pro­ce­du­res (even in a home set­ting) inclu­ding a heat tre­at­ment, i.e., boi­ling, to fur­t­her redu­ce micro­bi­al hazards.

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Unter­ernäh­rung / Vit­amin­man­gel

Vit­amin­man­gel (abs­tract)

Morin­ga Olei­fe­ra in Mal­nut­ri­ti­on: A Com­pre­hen­si­ve Review.

Curr Drug Dis­cov Tech­nol. 2019 Nov 5. doi: 10.2174/1570163816666191105162722. Online ahead of print.

Nut­ri­tio­nal defi­ci­en­cy is a major con­cern in deve­lo­ping coun­tries resul­ting in serious health con­se­quen­ces like men­tal and phy­si­cal growth retar­da­ti­on. Morin­ga oleifera(Moringa), a nut­ri­tious plant­gro­wing in tro­pi­cal regi­ons of deve­lo­ping coun­tries, is a can­di­da­te for over­co­m­ing nut­ri­tio­nal defi­ci­en­cy. Morin­ga lea­ves are rich in pro­te­in inclu­ding Sul­phur con­tai­ning ami­no acids.It con­ta­ins high amounts of vit­amin C than oran­ges, hig­her con­cen­tra­ti­on of vit­amin A than car­rots, hig­her cal­ci­um con­tent than milk and more pot­as­si­um than bana­nas. Moreo­ver, the­re is 9 times more iron in morin­ga than spi­n­ach, 4 times more fiber than oat. This review is enligh­ten­ing and explo­ring the nut­ri­tio­nal diver­si­fi­ca­ti­on of Morin­ga olei­fe­ra and other bene­fits which make it a bet­ter choice to use in our dai­ly diet to com­bat the situa­ti­on of mal­nut­ri­ti­on.

 

Krebs

Krebs (full text)

month: 12     year: 2018

Bio­med Phar­ma­co­ther. 2018 Dec;108:457–466. doi: 10.1016/j.biopha.2018.09.060. Epub 2018 Sep 18.

Morin­ga olei­fe­ra and their phy­ton­a­no­par­ti­cles: Poten­ti­al anti­pro­li­fe­ra­ti­ve agents against can­cer.

Can­cer is clas­si­fied as one of the lea­ding cau­ses of glo­bal mor­ta­li­ty. It has affec­ted mil­li­ons of peop­le, often with poor pro­gno­sis. Having seve­re side-effects with con­ven­tio­nal che­mo­the­ra­py, alter­na­te drugs and the­ra­pies are actively being inves­ti­ga­ted. The­re is a need for inno­va­ti­ve drug dis­co­very and design as exis­ting can­cer the­ra­pies are cost­ly and not readi­ly avail­ab­le. Ayur­ve­da and tra­di­tio­nal medi­ci­ne have uti­li­sed natu­ral resour­ces such as plants and trees as part of their regime to tre­at various ill­ness and disea­ses with posi­ti­ve out­co­mes. One such tree is Morin­ga olei­fe­ra (MO). Almost all parts have shown to be effec­tive against several ail­ments inclu­ding can­cer which was attri­bu­t­ed to the bioac­tive con­sti­tu­ents. Tar­ge­ted the­ra­pies had led to the deve­lop­ment of nano­par­ti­cles which are extre­me­ly effec­tive in various bio­me­di­cal app­li­ca­ti­ons due to their small size. Green syn­the­sis of gold nano­par­ti­cles have gre­at poten­ti­al as natu­ral­ly occur­ring plants and trees such as MO can be used in the syn­the­sis pro­cess. The resul­tant gold phy­ton­a­no­par­ti­cles are use­ful in can­cer the­ra­pies with impro­ved sur­vi­val rates and qua­li­ty of life. The review high­lights the impor­t­an­ce of MO in natu­ral medi­ci­ne, syn­the­sis of phy­ton­a­no­par­ti­cles and the fun­da­men­tal role as a poten­ti­al anti­pro­li­fe­ra­ti­ve agent against can­cer.

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Krebs (full text)

The In Vitro and In Vivo Anti­can­cer Pro­per­ties of Morin­ga olei­fe­ra.

Evid Based Com­ple­ment Alter­nat Med. 2018 Nov 14;2018:1071243. doi: 10.1155/2018/1071243. eCollec­tion 2018.

Morin­ga olei­fe­ra, a fast-gro­wing deci­duous tree that is wide­ly cul­ti­va­ted in tro­pi­cal and sub­tro­pi­cal regi­ons of the world, is well known for its abundant uses. The tree is a source of food, shel­ter, and tra­di­tio­nal medi­ci­ne for many peop­le, espe­ci­al­ly in deve­lo­ping coun­tries. Many stu­dies have been con­duc­ted to eva­lua­te the various claims of tra­di­tio­nal medi­ci­ne prac­titio­ners that the morin­ga tree can impro­ve health and tre­at various disea­ses. The tree has a high nut­ri­tio­nal pro­fi­le, espe­ci­al­ly the nut­ri­ent rich lea­ves. Some reports also sup­port the use of parts of the tree to redu­ce blood sugar and cho­le­ste­rol levels. The­se attrac­tive pro­per­ties have led rese­ar­chers to look for other novel uses for the morin­ga tree, espe­ci­al­ly as a source of anti­can­cer drugs. Rese­ar­chers have tested extracts from various parts of the morin­ga tree both in vitro and in vivo on several types of can­cers with vary­ing suc­cess. This review explo­res the sta­te of cur­rent rese­arch on the anti­can­cer pro­per­ties of M. olei­fe­ra.

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Krebs (full text)

Morin­ga olei­fe­ra Lam: Tar­ge­ting Chemo­pre­ven­ti­on.

Asi­an Pac J Can­cer Prev. 2016;17(8):3675–86.

Morin­ga olei­fe­ra Lam, fami­ly Moring­aceae, is a peren­ni­al plant which is cal­led various names, but is local­ly known in Malay­sia as „murungai“ or „kelor“. Glu­co­morin­gin, a glu­co­si­no­la­te with from M. olei­fe­rais a major secon­da­ry meta­bo­li­te com­po­und. The seeds and lea­ves of the plant are repor­ted to have the hig­hest amount of glu­co­si­no­la­tes. M. olei­fe­ra is well known for its many uses health and bene­fits. It is clai­med to have nut­ri­tio­nal, medi­c­inal and chemo­pre­ven­ti­ve poten­ti­als. Chemo­pre­ven­ti­ve effects of M. olei­fe­ra are expec­ted due to the exis­tence of glu­co­si­no­la­te which it is repor­ted to have the abi­li­ty to indu­ce apo­pto­sis in anti­can­cer stu­dies. Fur­ther­mo­re, chemo­pre­ven­ti­ve value of M. olei­fe­ra has been demons­tra­ted in stu­dies uti­li­zing its leaf extract to inhi­bit the growth of human can­cer cell lines. This review high­lights the advan­ta­ges of M. olei­fe­ra tar­ge­ting chemo­pre­ven­ti­on whe­re glu­co­si­no­la­tes could help to slow the pro­cess of car­ci­no­ge­ne­sis through several mole­cu­lar tar­gets. It is also inclu­des inhi­bi­ti­on of car­ci­no­gen activa­ti­on and induc­tion of car­ci­no­gen deto­xi­fi­ca­ti­on, anti-inflamma­to­ry, anti-tumor cell pro­li­fe­ra­ti­on, induc­tion of apo­pto­sis and inhi­bi­ti­on of tumor angio­ge­ne­sis. Final­ly, for syn­er­gistic effects of M. olei­fe­ra with other drugs and safe­ty, essen­ti­al for chemo­pre­ven­ti­on, it is important that it safe to be con­su­med by human body and works well. Alt­hough the­re is pro­mi­sing evi­dence about M. olei­fe­ra in chemo­pre­ven­ti­on, exten­si­ve rese­arch needs to be done due to the expec­ted rise of can­cer in com­ing years and to gain more infor­ma­ti­on about the mecha­nisms invol­ved in M. olei­fe­ra influ­ence, which could be a good source to inhi­bit several major mecha­nisms invol­ved in can­cer deve­lop­ment.

 

Oxi­da­ti­ver / nitro­sa­ti­ver Stress

Oxi­da­ti­ver / nitro­sa­ti­ver Stress (abs­tract)

month: (abs­tract)

07  / year: 2020

Mini Rev Med Chem. 2020 Jul 28. doi: 10.2174/1389557520999200728162453. Online ahead of print.

Morin­ga Olei­fe­ra: A Review of Its Occur­rence, Phar­ma­co­lo­gi­cal Impor­t­an­ce and Oxi­da­ti­ve stress.

Oxi­da­ti­ve / nitro­sa­ti­ve stress can be cau­sed by exces­si­ve pro­duc­tion of ROS and RNS with meta­bo­lic reac­tions that chan­ge balan­ce in favor of oxid­ants in cases whe­re oxid­ants increa­se and anti­oxi­d­ants decrea­se in orga­nisms using oxy­gen. ROS and RNS react with several bio­lo­gi­cal macro­mole­cu­les in cell, such as car­bo­hy­dra­tes, nucleic acids, lipids, and pro­te­ins, and alter their func­tions. Some natu­ral anti­oxi­d­ants are con­stant­ly being rese­ar­ched for their bene­fits in terms of human health, which can streng­t­hen the body’s anti­oxi­dant defen­se sys­tem and have the poten­ti­al to sca­ven­ger free radi­cals. It is a well-known and prac­tical stra­te­gy to pre­vent and / or tre­at disea­ses due to the con­sump­ti­on of more sui­ta­ble fruits, herbs, spi­ces and vege­ta­bles and the pre­sence of bioac­tive anti­oxi­dant com­pounds. Morin­ga olei­fe­ra, a new and important one of the­se plants, has a wide ran­ge of bioac­tive com­pounds that can be obtai­ned in dif­fe­rent her­bal struc­tures such as lea­ves, seeds, stems and shells. It con­sists of bioac­tive mole­cu­les such as phe­n­o­lic com­pounds, fats, fat­ty acids, car­bo­hy­dra­tes, pro­te­ins, func­tio­nal pep­ti­des, vit­amins, mine­rals and essen­ti­al ami­no acids as well as a num­ber of gly­co­si­des and have gre­at poten­ti­al for use in various for­mu­la­ti­ons in various health and food pro­ducts. This review high­lights the for­ma­ti­on of MO, its impor­t­an­ce in natu­ral medi­ci­ne, its phar­ma­co­lo­gi­cal value, and its role as a pos­si­ble anti-pro­li­fe­ra­ti­ve agent against can­cer and its use in some disea­ses.

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Ent­zün­dung

Ent­zün­dung / Full Text

Morin­ga Lea­ves Pre­vent Hepa­tic Lipid Accu­mu­la­ti­on and Inflamma­ti­on in Gui­nea Pigs by Redu­cing the Expres­si­on of Genes Invol­ved in Lipid Meta­bo­lism.

Int J Mol Sci. 2017 Jun 22;18(7). pii: E1330. doi: 10.3390/ijms18071330.

To inves­ti­ga­te the mecha­nisms by which Morin­ga olei­fe­ra lea­ves (ML) modu­la­te hepa­tic lipids, gui­nea pigs were allo­ca­ted to eit­her con­trol (0% ML), 10% Low Morin­ga (LM) or 15% High Morin­ga (HM) diets with 0.25% die­ta­ry cho­le­ste­rol to indu­ce hepa­tic steato­sis. After 6 weeks, gui­nea pigs were sacri­fi­ced and liver and plas­ma were collec­ted to deter­mi­ne plas­ma lipids, hepa­tic lipids, cyto­ki­nes and the expres­si­on of genes invol­ved in hepa­tic cho­le­ste­rol (CH) and tri­gly­ce­ri­de (TG) meta­bo­lism. The­re were no dif­fe­ren­ces in plas­ma lipids among groups. A dose-respon­se effect of ML was obser­ved in hepa­tic lipids (CH and TG) with the lowest con­cen­tra­ti­ons in the HM group (p < 0.001), con­sis­tent with his­to­lo­gi­cal eva­lua­ti­on of lipid drop­lets. Hepa­tic gene expres­si­on of digly­ce­ri­de acyl­trans­fe­ra­se-2 and per­o­x­isome pro­li­fe­ra­tor activa­ted recep­tor-γ, as well as pro­te­in con­cen­tra­ti­ons inter­leu­kin (IL)-1β and inter­fe­ron-γ, were lowest in the HM group (p < 0.005). Hepa­tic gene expres­si­on of clus­ter of dif­fe­ren­tia­ti­on-68 and ste­rol regu­la­to­ry ele­ment bin­ding pro­te­in-1c were 60% lower in both the LM and HM groups com­pa­red to con­trols (p < 0.01). This stu­dy demons­tra­tes that ML may pre­vent hepa­tic steato­sis by affec­ting gene expres­si­on rela­ted to hepa­tic lipids syn­the­sis resul­ting in lower con­cen­tra­ti­ons of cho­le­ste­rol and tri­gly­ce­rides and redu­ced inflamma­ti­on in the liver.

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Ent­zün­dung / Abs­tract

Anti­oxi­dant, anti-inflamma­to­ry and anti­ar­thri­tic poten­ti­al of Morin­ga olei­fe­ra Lam: An eth­no­me­di­c­inal plant of Moring­aceae fami­ly

Ent­zün­dung / Abs­tract

Medi­c­inal plants are increa­singly being eva­lua­ted for the tre­at­ment of chro­nic dis­or­ders. This stu­dy was aimed at asses­sing anti-arthri­tic poten­ti­al of Morin­ga olei­fe­ra (wild type). Dif­fe­rent extracts of the plant lea­ves were pre­pa­red and eva­lua­ted for the pre­sence and quan­ti­fi­ca­ti­on of phy­to­che­mi­cals. The plant extracts were asses­sed for in vitro anti­oxi­dant activi­ty by dif­fe­rent methods fol­lo­wed by in vitro anti-inflamma­to­ry assays such as pro­te­in dena­tu­ra­ti­on, mem­bra­ne sta­bi­li­za­ti­on and anti-pro­teinase activi­ties. The plant extracts were fur­t­her asses­sed in Wistar rats by form­alde­hy­de indu­ced arthri­tis model at 150, 300 and 600 mg/kg dosa­ge level. Che­mi­cal ana­ly­sis show­ed that metha­no­lic and aqueous extracts con­tai­ned the hig­hest total phe­n­o­lic and fla­vo­no­id con­tents. Kaemp­fe­rol, gal­lic acid, vanil­lic acid, cou­ma­ric acid and quer­ce­tin were detec­ted and quan­ti­fied in the plant extracts. It was found that the metha­no­lic, aqueous and ethyl ace­ta­te extracts had exhi­bi­ted the maxi­mum in vitro anti­oxi­dant poten­ti­al. The­se extracts also exhi­bi­ted a decrea­se in pro­te­in dena­tu­ra­ti­on, pre­ven­ted lysis of red blood cell mem­bra­nes and show­ed anti-pro­teinase activi­ties. The­se extracts show­ed signi­fi­cant inhi­bi­ti­on in paw inflamma­ti­on and pre­ven­ted arthri­tis indu­ced anemia and weight loss in rats in dose depen­dent man­ner. The out­co­mes of this rese­arch indi­ca­ted that all extracts of M. olei­fe­ra had exer­ted signi­fi­cant anti­oxi­dant and anti-arthri­tic poten­ti­al in rats in dose depen­dent man­ner. Anti-arthri­tic activi­ty of M. olei­fe­ra might be due to the sca­ven­ging of free radi­cals, inhi­bi­ti­on of pro­te­in dena­tu­ra­ti­on, mem­bra­ne sta­bi­li­za­ti­on and anti-pro­teinase activi­ty.

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Ent­zün­dung / Abs­tract

Quer­ce­tin alle­via­tes inflamma­ti­on after short-term tre­at­ment in high-fat-fed mice.

Food Funct. 2013 Jun;4(6):889–98. doi: 10.1039/c3fo30241e. Epub 2013 May 3.
Con­sump­ti­on of a high-fat diet (HFD) pro­mo­tes reac­tive oxy­gen spe­ci­es (ROS) which ulti­mate­ly trig­ger inflamma­ti­on. The aim of this stu­dy was to inves­ti­ga­te the role of Morin­ga olei­fe­ra leaf extract (MoLE) and its active com­po­nent quer­ce­tin in pre­ven­ting NF-κB-media­ted inflamma­ti­on rai­sed by short-term HFD. Quer­ce­tin was found to be one of the major fla­vo­no­id com­pon­ents from HPLC of MoLE. Swiss mice were fed for 15 days on HFD, both with or without MoLE/quercetin. The anti­oxi­dant pro­fi­le was esti­ma­ted from liver homo­gena­te. NF-κB and some rele­vant inflamma­to­ry mar­kers were eva­lua­ted by immu­no­blot­ting, RT-PCR and ELISA. Signi­fi­cant­ly (P < 0.05) lower anti­oxi­dant pro­fi­le and hig­her lipid per­oxi­da­ti­on was found in HFD group com­pa­red to con­trol (P < 0.05). Increa­sed nuclear import of NF-κB and ele­va­ted expres­si­ons of pro-inflamma­to­ry mar­kers were fur­t­her mani­fes­ta­ti­ons in the HFD group. All the­se chan­ges were rever­sed in the MoLE/quer­ce­tin-trea­ted groups with signi­fi­cant impro­ve­ment of anti­oxi­dant activi­ty com­pa­red to the HFD group. MoLE was found to be rich in poly­phe­n­ols and both MoLE and quer­ce­tin show­ed potent free radi­cal and hydroxyl radi­cal quen­ching activi­ty. Thus, the pre­sent stu­dy con­clu­ded that short-term tre­at­ment with MoLE and its con­sti­tu­ent quer­ce­tin pre­vent HFD-media­ted inflamma­ti­on in mice. … Read More

 

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Ent­zün­dung / Full Text

Sys­te­ma­tic Review of Morin­ga oleifera’s Poten­ti­al as Anti­bac­te­ri­al and Anti­In­flamma­to­ry in the Oral Cavi­ty

Mut­main­nah Nurul , Ach­mad Muham­mad Harun

Abs­tract: Intro­duc­tion: Morin­ga plant is a plant that is spread throug­hout the regi­on in Indo­ne­sia and has many bene­fits. Morin­ga olei­fe­ra L. plant is also known as the “mira­cle of tree” becau­se almost all parts of the plant, from the lea­ves, bark, seeds, fruit of morin­ga to the roots are used by humans, espe­ci­al­ly as tra­di­tio­nal medi­ci­ne. Morin­ga has been pro­ven effec­tive as anti­bac­te­ri­al and anti-inflamma­to­ry, for examp­le in toot­h­pas­te, mou­th­wash, and root canal irri­ga­ti­on from chi­to­san. So this sys­te­ma­tic review reviews some of the lite­ra­tu­re on the poten­ti­al of morin­ga plants as anti­bac­te­ri­al and anti­in­flamma­to­ry in the oral cavi­ty. Methods: In this sys­te­ma­tic review, arti­cle sear­ches were con­duc­ted on Goog­le Search and Pubmed. Stu­dies published from 2011 to 2020. 104 arti­cles were rated, inclu­ding 104 arti­cles from elec­tro­nic data­ba­ses, 0 from manu­al search. 96 records were scree­ned, 63 records were exclu­ded, 33 full-text arti­cles were asses­sed for eli­gi­bi­li­ty and 17 full-text arti­cles were inclu­ded. Result: The­re are 8 arti­cles about anti­bac­te­ri­al of Morin­ga olei­fe­ra and 10 arti­cles about anti-inflamma­to­ry of Morin­ga olei­fe­ra. Con­clu­si­on: Based on 18 arti­cles show that chi­to­san is very poten­ti­al as a her­bal plant that can be anti­bac­te­ri­al and anti-inflamma­to­ry in the oral cavi­ty.

Key­wor­ds: Morin­ga olei­fe­ra, Anti­bac­te­ri­al, Anti-inflamma­to­ry, Oral cavi­ty

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Ent­zün­dung / Abs­tract

Alle­via­ti­on of lead ace­ta­te-indu­ced nephro­to­xi­ci­ty by Morin­ga olei­fe­ra extract in rats: high­lighting the anti­oxi­dant, anti-inflamma­to­ry, and anti-apo­p­totic activi­ties

Abs­tract

Lead (Pb) is an envi­ron­men­tal toxi­cant; its con­sump­ti­on can indu­ce renal defi­cits. In this stu­dy, we explo­red the pos­si­ble pro­tec­tive effi­ci­en­cy of Morin­ga olei­fe­ra extract (MOE) against lead ace­ta­te (PbAc)-mediated repro­to­xi­ci­ty. Four expe­ri­men­tal groups of seven rats each were used: con­trol, PbAc, MOE, and MOE+PbAc groups. All groups were given their respec­tive tre­at­ment for 4 weeks. PbAc impai­red the oxidative/antioxidative balan­ce in the renal tis­sue, as shown by the decrea­sed anti­oxi­dant pro­te­ins (glut­a­thio­ne, glut­a­thio­ne reduc­ta­se, glut­a­thio­ne per­oxi­da­se, cata­la­se, and super­oxi­de dis­mu­ta­se) and increa­sed oxid­ants (lipid per­oxi­da­ti­on and nitric oxi­de). Addi­tio­nal­ly, PbAc enhan­ced the pro­gres­si­on of kid­ney inflamma­ti­on by increa­sing tumor necro­sis fac­tor-alpha, inter­leu­kin-1 beta, and nuclear fac­tor kap­pa B asso­cia­ted with upre­gu­la­ti­on of indu­ci­ble nitric oxi­de syn­t­ha­se. Moreo­ver, a dys­re­gu­la­ti­on in the apo­p­totic-regu­la­ting pro­te­ins (Bax, cas­pa­se-3, and Bcl2) were recor­ded upon PbAc expo­sure. Remar­kab­ly, MOE oral admi­nis­tra­ti­on res­to­red redox home­o­stasis, sup­pres­sed the inflamma­to­ry and apo­p­totic respon­ses in the kid­ney tis­sue. Our fin­dings point out that MOE could be used as an alter­na­ti­ve reme­dy to over­co­me the adver­se effects of Pb expo­sure, which may be due to its potent anti­oxi­dant, anti-inflamma­to­ry, and anti-apo­p­totic effects.